Aceplee-D Tablet

Introduction

Aceplee-D is a prescription medication that contains two active ingredients: Aceclofenac and Diacerein. It is commonly prescribed to manage pain and inflammation associated with various conditions, such as osteoarthritis.

Uses

Aceplee-D is primarily used to relieve pain and reduce inflammation in patients with osteoarthritis. Osteoarthritis is a condition that causes the breakdown of cartilage in the joints, leading to joint pain, stiffness, and swelling. By inhibiting the production of certain chemicals in the body that cause inflammation, Aceplee-D helps alleviate these symptoms and improve joint function.

Dosage and Administration

follow your doctor’s instructions regarding dosage and administration of Aceplee-D. The typical recommended dose for adults is usually one tablet taken orally, with or without food, once or twice daily. However, the specific dosage may vary depending on the severity of your condition and your individual response to the medication. Always take the medication as prescribed and do not exceed the recommended dose.

Mechanism of Action

Aceclofenac, one of the active ingredients in Aceplee-D, belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of prostaglandins, which are substances involved in the process of inflammation. By reducing the levels of prostaglandins, Aceclofenac helps alleviate pain and inflammation in the joints.

Diacerein, the other active ingredient in Aceplee-D, works by inhibiting the production of interleukin-1 beta, a protein that plays a role in the inflammatory process. By reducing the levels of interleukin-1 beta, Diacerein helps reduce inflammation and improve symptoms in patients with osteoarthritis.

Side Effects

Common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache

If you experience any of these side effects and they persist or worsen, consult your doctor.

In some cases, Aceplee-D may cause more serious side effects, such as:

• Severe allergic reactions, including rash, itching, swelling, or difficulty breathing
• Stomach ulcers or bleeding
• Liver damage
• Kidney problems

If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

inform your doctor about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, before starting Aceplee-D.

Aceplee-D may interact with certain medications, including:

• Anticoagulants (blood thinners)
• Other NSAIDs
• Diuretics
• Methotrexate
• Lithium

These are not the only possible drug interactions. Therefore, consult your doctor or pharmacist to ensure the safe use of Aceplee-D with your current medications.

Precautions

Before taking Aceplee-D, inform your doctor about any pre-existing medical conditions, including:

• A history of stomach ulcers or bleeding
• Liver or kidney problems
• Asthma or other respiratory disorders
• Heart disease or high blood pressure
• Pregnancy or breastfeeding

Aceplee-D should be used with caution in patients with these conditions, as it may increase the risk of certain side effects.

Additionally, avoid alcohol consumption while taking Aceplee-D, as it may increase the risk of stomach bleeding and liver damage.

Storage

Patient Tips

• Take Aceplee-D exactly as prescribed by your doctor. Do not exceed the recommended dose.
• If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not crush, chew, or break the tablet. Swallow it whole with a glass of water.
• If you experience any unusual symptoms or side effects while taking Aceplee-D, contact your doctor immediately.
• It may take some time for Aceplee-D to provide maximum benefit. Be patient and continue taking the medication as directed.
• Attend regular follow-up appointments with your doctor to monitor your response to the medication and discuss any concerns or questions you may have.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Aceclofenac 100 mg Film-coated Tablets (Health Professionals SmPC) Available at:
• ACECLOFENAC 100MG TABLETS (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• Negi S, Tandel N, Sharma P, Kumar R, Tyagi RK. Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation. Drug Discov Today. 2023 Aug;28(8):103671. doi: 10.1016/j.drudis.2023.103671. Epub 2023 Jun 16. [Accessed 25 Jun. 2024] Available at:
• Serrapeptase (International database) (Drugs.com) [Accessed 23 Jun. 2024] (online) Available at: