Acticross MR 100mg/325mg/250mg Tablet

Introduction

Acticross MR is a prescription medication that combines three active ingredients: Aceclofenac, Paracetamol, and Chlorzoxazone. It is commonly used to provide relief from pain and inflammation associated with conditions such as arthritis, muscle spasms, and joint disorders.

Uses

Acticross MR is primarily prescribed to manage pain and reduce inflammation in various conditions, including:

• Arthritis: It can help alleviate the pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
• Muscle Spasms: Acticross MR can provide relief from muscle spasms and stiffness, often caused by sprains, strains, or musculoskeletal disorders.
• Joint Disorders: It may be used to ease pain and reduce inflammation in conditions like gout or bursitis.

Dosage and Administration

follow the dosage instructions provided by your healthcare professional. The typical dosage for Acticross MR is one tablet taken orally, usually two to three times a day. The exact dosage and frequency may vary depending on the severity of your condition and your individual response to the medication.

It is recommended to take Acticross MR with or after meals to reduce the risk of stomach upset. Swallow the tablet whole with a glass of water, without crushing or chewing it.

Mechanism of Action

Acticross MR contains three active ingredients with different mechanisms of action:

• Aceclofenac: It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and works by reducing the production of certain chemicals in the body that cause pain and inflammation.
• Paracetamol: It is a pain reliever and fever reducer that works by blocking the production of certain chemicals involved in the transmission of pain signals.
• Chlorzoxazone: It acts as a muscle relaxant by interfering with the nerve impulses responsible for muscle contractions, helping to relieve muscle spasms and stiffness.

Together, these ingredients work synergistically to provide effective pain relief and reduce inflammation.

Side Effects

Common side effects may include:

• Upset stomach
• Nausea or vomiting
• Headache
• Dizziness
• Drowsiness

If any of these side effects persist or worsen, it is advised to consult your healthcare professional.

In rare cases, Acticross MR may cause more serious side effects. These can include:

• Allergic reactions (rash, itching, swelling, difficulty breathing)
• Severe stomach pain or black stools
• Signs of liver problems (yellowing of the skin or eyes, dark urine, persistent nausea)
• Signs of kidney problems (decreased urine output, swelling in the ankles or feet)

If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Acticross MR may interact with certain medications, potentially affecting their efficacy or increasing the risk of side effects. Inform your healthcare professional about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins.

Some common drug interactions to be aware of include:

• Blood-thinning medications (e.g., warfarin): Acticross MR may increase the risk of bleeding when taken together with blood-thinning drugs.
• Diuretics (e.g., furosemide): The combination of Acticross MR and diuretics may lead to an increased risk of kidney problems.
• Other NSAIDs: Taking Acticross MR with other NSAIDs may increase the risk of side effects.

This is not an exhaustive list of drug interactions. Always consult your healthcare professional for personalized advice.

Precautions

Before taking Acticross MR, consider the following precautions:

• Allergies: Inform your healthcare professional if you have any known allergies to Aceclofenac, Paracetamol, Chlorzoxazone, or any other medications.
• Pre-existing Conditions: Acticross MR may not be suitable for individuals with certain health conditions, such as a history of stomach ulcers, liver or kidney disease, or asthma.
• Pregnancy and Breastfeeding: consult your healthcare professional before using Acticross MR if you are pregnant, planning to become pregnant, or breastfeeding.
• Interactions with Other Medications: Inform your healthcare professional about all the medications you are currently taking to avoid potential drug interactions.

Storage

Patient Tips

• Take Acticross MR as prescribed by your healthcare professional. Do not exceed the recommended dosage.
• If you experience any side effects or have concerns, contact your healthcare professional.
• Avoid consuming alcohol while taking Acticross MR, as it may increase the risk of certain side effects.
• Do not drive or operate heavy machinery if you feel drowsy or dizzy after taking the medication.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Paracetamol for adults: painkiller for pain and high temperature (NHS UK) [Accessed 17 Jun. 2024] (online) Available at:
• Aceclofenac 100 mg Film-coated Tablets (Health Professionals SmPC) Available at:
• ACECLOFENAC 100MG TABLETS (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• chlorzoxazone (RX) [Accessed 10 Jun. 2024] (online) Available at:
• Chlorzoxazone (MedlinePlus) [Accessed 22 Jun. 2024] (online) Available at:
• Negi S, Tandel N, Sharma P, Kumar R, Tyagi RK. Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation. Drug Discov Today. 2023 Aug;28(8):103671. doi: 10.1016/j.drudis.2023.103671. Epub 2023 Jun 16. [Accessed 25 Jun. 2024] Available at: