Afinitor 5mg Tablet

Introduction

Afinitor is a prescription medication that contains the active ingredient Everolimus. It is available under the brand name Afinitor. This medication is primarily used for the treatment of certain types of cancer and certain non-cancerous tumors.

Uses

Afinitor is prescribed for various conditions, including:

• Advanced renal cell carcinoma (a type of kidney cancer)
• Advanced hormone receptor-positive, HER2-negative breast cancer
• Neuroendocrine tumors of pancreatic origin (PNET)
• Subependymal giant cell astrocytoma (SEGA), a non-cancerous brain tumor associated with tuberous sclerosis complex (TSC)

Dosage and Administration

The dosage of Afinitor may vary depending on the specific condition being treated and other individual factors. Follow the instructions provided by your healthcare professional. Generally, the tablet is taken once daily, with or without food. Swallow the tablet whole with a glass of water, without crushing or chewing it.

Mechanism of Action

Everolimus, the active ingredient in Afinitor, belongs to a class of medications known as mTOR inhibitors. It works by inhibiting the activity of a protein called mammalian target of rapamycin (mTOR), which plays a role in cell growth and division. By blocking mTOR, Everolimus helps to slow down or stop the growth of cancer cells or non-cancerous tumors.

Side Effects

Common side effects may include:

• Fatigue
• Infections
• Mouth sores
• Diarrhea
• Nausea
• Rash or skin reactions

Serious side effects are less common but may include:

• Severe allergic reactions
• Lung or breathing problems
• Kidney problems
• Liver problems
• High blood sugar levels

If you experience any concerning side effects or have any questions, contact your healthcare professional immediately.

Drug Interactions

Afinitor may interact with other medications. Inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal products. Some medications that may interact with Afinitor include:

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
• Strong CYP3A4 inducers (e.g., rifampin, phenytoin)
• Certain antifungal medications
• Certain antibiotics

These are not all the possible drug interactions. Your healthcare professional can provide more detailed information and guidance.

Precautions

Before taking Afinitor, discuss your medical history and any other medications or substances you are taking with your healthcare professional. Precautions and contraindications may include:

• Hypersensitivity to Everolimus or any other ingredients in the tablet
• Severe liver impairment
• Impaired lung function
• History of infections
• Pregnancy or breastfeeding

follow all precautionary measures and inform your healthcare professional about any changes in your health or medications.

Storage

Afinitor should be stored in a cool and dry place, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

Here are some additional tips for patients using Afinitor:

• Take the medication at the same time each day to help establish a routine.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not change your dose or stop taking the medication without consulting your healthcare professional.
• Maintain regular follow-up appointments with your healthcare professional to monitor your progress and manage any potential side effects.
• Be cautious while driving or operating machinery, as Afinitor may cause dizziness or fatigue.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Afinitor 10mg tablets (Health Professionals SmPC) Available at:
• Everolimus (Drugs.com) [Accessed 13 Jun. 2024] (online) Available at:
• everolimus (antineoplastic) 5 mg tablet for oral suspension antineoplastic – mtor kinase inhibitors (RX) [Accessed 20 Jun. 2024] (online) Available at:
• Everolimus (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Hasskarl J. Everolimus. Recent Results Cancer Res. 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. [Accessed 13 Jun. 2024] Available at: