Alrista Plus Tablet SR

Introduction

Alrista Plus SR is a prescription medication that contains the active ingredients Epalrestat and Methylcobalamin. It is available in tablet form and is primarily used for the treatment of certain nerve disorders.

Uses

Alrista Plus SR is commonly prescribed for the management of diabetic peripheral neuropathy, a condition that affects the nerves in the hands, feet, and legs due to diabetes. It helps to alleviate symptoms such as pain, numbness, and tingling sensations associated with this condition.

Dosage and Administration

The dosage of Alrista Plus SR may vary depending on the severity of the nerve disorder and individual patient factors. Follow your healthcare provider’s instructions carefully. Generally, the recommended dosage is one tablet taken orally once daily, preferably with meals. Swallow the tablet whole with a glass of water, without crushing or chewing it.

Mechanism of Action

Epalrestat, one of the active ingredients in Alrista Plus SR, belongs to a class of medications called aldose reductase inhibitors. It works by reducing the activity of an enzyme called aldose reductase, which is involved in the development of diabetic neuropathy. By inhibiting this enzyme, Epalrestat helps to prevent nerve damage and improve nerve function.

Methylcobalamin, the other active ingredient, is a form of vitamin B12 that plays a crucial role in the maintenance and repair of nerve cells. It helps to support healthy nerve function and may help to reduce nerve pain and discomfort.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, dizziness, headache, and skin rash. These side effects are usually mild and do not require medical attention unless they persist or worsen.

Serious side effects are rare but can occur. If you experience any of the following, seek immediate medical attention: severe allergic reactions (such as rash, itching, swelling, severe dizziness, or difficulty breathing), unusual bleeding or bruising, signs of liver problems (such as yellowing of the skin or eyes, dark urine, or persistent nausea), or signs of anemia (such as tiredness, pale skin, or shortness of breath).

Drug Interactions

inform your healthcare provider about all medications you are currently taking, including prescription, over-the-counter, and herbal products, as they may interact with Alrista Plus SR. Some common drug interactions include:

• Warfarin: Alrista Plus SR may increase the risk of bleeding if taken with warfarin or other blood-thinning medications.
• Metformin: There may be an increased risk of vitamin B12 deficiency when Alrista Plus SR is taken with metformin, a medication commonly used to treat diabetes.
• Other neuropathy medications: Combining Alrista Plus SR with other medications used to treat neuropathy may increase the risk of side effects or drug interactions. Discuss all medications with your healthcare provider.

Precautions

Before starting treatment with Alrista Plus SR, inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking. This medication may not be suitable for everyone, and certain precautions should be taken, including:

• Pregnancy and breastfeeding: Alrista Plus SR should be used with caution during pregnancy and breastfeeding. Discuss the potential risks and benefits with your healthcare provider.
• Liver or kidney problems: Alrista Plus SR may require dose adjustments or careful monitoring in patients with liver or kidney problems. Your healthcare provider will determine the appropriate dosage for you.
• Alcohol: It is recommended to avoid excessive alcohol consumption while taking Alrista Plus SR, as it may increase the risk of side effects or worsen existing liver problems.

Storage

Alrista Plus SR should be stored at room temperature, away from moisture and direct sunlight. Keep the medication out of reach of children and pets. Do not use the medication if it has passed the expiration date printed on the packaging. If you have any expired or unused medication, consult your pharmacist for proper disposal.

Patient Tips

Here are some additional tips to keep in mind while taking Alrista Plus SR:

• Take the medication at the same time each day to help establish a routine.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not exceed the recommended dosage without consulting your healthcare provider.
• If you experience any unusual or bothersome side effects, contact your healthcare provider for further guidance.
• Follow a healthy lifestyle, including regular exercise, a balanced diet, and managing your blood sugar levels if you have diabetes.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Methylcobalamin vitamin B12 (Drugs.com) [Accessed 25 Jun. 2024] (online) Available at:
• ABCD4 gene (MedlinePlus) [Accessed 5 Jun. 2024] (online) Available at:
• Steele JW, Faulds D, Goa KL. Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus. Drugs Aging. 1993 Nov-Dec;3(6):532-55. doi: 10.2165/00002512-199303060-00007. [Accessed 2 Jun. 2024] Available at:
• Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jan 27;13(2):395. doi: 10.3390/nu13020395. [Accessed 14 Jun. 2024] Available at: