Appella 100mg/500mg Capsule

Introduction

Appella is a medication that contains two active ingredients: Aceclofenac and Paracetamol. It is a prescription medication that is commonly used to treat pain and inflammation associated with conditions such as arthritis, osteoarthritis, and musculoskeletal disorders.

Uses

Appella is prescribed by healthcare professionals to provide relief from pain and reduce inflammation in various conditions, including:

• Arthritis: Appella can help alleviate pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and other types of arthritis.
• Musculoskeletal Disorders: It can also be used to manage pain and inflammation caused by musculoskeletal disorders, such as sprains, strains, and sports injuries.

Note that Appella should only be used under the guidance of a healthcare professional, who will determine the appropriate use of the medication based on individual needs and medical history.

Dosage and Administration

Appella should be taken as directed by your healthcare professional. The dosage and frequency of administration may vary depending on the severity of your condition and your individual response to the medication.

It is generally recommended to take Appella with a full glass of water, preferably with or after meals to minimize the risk of stomach upset. Do not crush or chew the capsules, as they are designed to release the medication slowly.

Always follow the instructions provided by your healthcare professional and do not exceed the prescribed dosage. If you have any questions or concerns about the dosage or administration of Appella, consult your healthcare professional.

Mechanism of Action

Appella contains two active ingredients, Aceclofenac and Paracetamol, which work together to provide pain relief and reduce inflammation.

• Aceclofenac belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of certain chemicals in the body that are responsible for pain and inflammation.
• Paracetamol is a medication that helps to relieve pain and reduce fever. Its exact mechanism of action is not fully understood, but it is thought to work by affecting certain chemicals in the brain that regulate pain and body temperature.

The combination of Aceclofenac and Paracetamol in Appella provides a dual action in managing pain and inflammation, offering effective relief for individuals with arthritis and musculoskeletal disorders.

Side Effects

Common side effects may include:

• Upset stomach
• Nausea
• Diarrhea
• Headache
• Dizziness

These side effects are usually mild and temporary, but if they persist or become bothersome, consult your healthcare professional.

In rare cases, Appella may cause more serious side effects. These can include:

• Allergic reactions (such as rash, itching, swelling, or difficulty breathing)
• Stomach ulcers or bleeding
• Liver problems (such as jaundice or liver inflammation)

If you experience any severe or persistent side effects, seek immediate medical attention.

Drug Interactions

Appella may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Some common drug interactions to be aware of include:

• Anticoagulant medications (such as warfarin): Appella may increase the risk of bleeding when taken with anticoagulants.
• Diuretics: The combination of Appella and diuretics may lead to decreased kidney function.
• Other NSAIDs: Concurrent use of Appella with other NSAIDs may increase the risk of side effects.

Your healthcare professional will carefully consider these potential interactions and adjust your medication regimen accordingly to ensure your safety and optimize treatment outcomes.

Precautions

Before taking Appella, inform your healthcare professional about any medical conditions you have, including allergies, liver or kidney problems, gastrointestinal disorders, or a history of stomach ulcers. This information will help your healthcare professional make an informed decision about whether this medication is suitable for you.

Additionally, be cautious when using Appella if you:

• Are pregnant or breastfeeding: Appella should be used with caution during pregnancy or while breastfeeding. Your healthcare professional will weigh the potential benefits against the potential risks for you and your baby.
• Have a history of asthma or other respiratory conditions: NSAIDs, including Aceclofenac, may worsen respiratory conditions in some individuals.
• Are taking other medications or supplements: Discuss all your current medications and supplements with your healthcare professional to avoid potential interactions.

Storage

Appella should be stored in a cool and dry place, away from direct sunlight and moisture. Follow the storage instructions provided on the packaging, and keep it out of reach of children.

Patient Tips

• Take Appella as directed by your healthcare professional. Do not exceed the prescribed dosage or duration of treatment.
• If you experience any unusual or severe side effects while taking Appella, contact your healthcare professional immediately.
• Inform your healthcare professional about any other medications, supplements, or herbal products you are taking to avoid potential interactions.
• follow a well-balanced diet, exercise regularly, and maintain a healthy lifestyle while taking Appella to optimize treatment outcomes.
• Attend regular check-ups with your healthcare professional to monitor your progress and adjust your treatment if necessary.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Paracetamol for adults: painkiller for pain and high temperature (NHS UK) [Accessed 17 Jun. 2024] (online) Available at:
• Aceclofenac 100 mg Film-coated Tablets (Health Professionals SmPC) Available at:
• ACECLOFENAC 100MG TABLETS (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• paracetamol tablet (OTC) [Accessed 9 Jun. 2024] (online) Available at:
• Acetaminophen Level: MedlinePlus Medical Test (MedlinePlus) [Accessed 23 Jun. 2024] (online) Available at: acetaminophen-level” rel=”noreferrer noopener” target=”_blank”>
• Negi S, Tandel N, Sharma P, Kumar R, Tyagi RK. Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation. Drug Discov Today. 2023 Aug;28(8):103671. doi: 10.1016/j.drudis.2023.103671. Epub 2023 Jun 16. [Accessed 25 Jun. 2024] Available at: