Arnipin 100 Tablet

Introduction

Arnipin is a prescription medication that combines two active ingredients: Sacubitril and Valsartan. It is commonly used to treat heart failure with reduced ejection fraction in adult patients.

Uses

Arnipin is prescribed for the management of chronic heart failure in adults who have symptoms despite optimal medical therapy. It is specifically indicated for patients with reduced ejection fraction.

Dosage and Administration

The dosage of Arnipin will be determined by your healthcare provider based on your individual needs and medical condition. Follow their instructions carefully. The tablets are usually taken orally, with or without food. Swallow the tablet whole, without crushing or chewing it.

Mechanism of Action

Arnipin contains two active ingredients with different mechanisms of action. Sacubitril is a neprilysin inhibitor, which helps increase the levels of beneficial peptides in the body that promote vasodilation and reduce sodium and fluid retention. Valsartan is an angiotensin receptor blocker (ARB) that works by blocking the action of a hormone called angiotensin II, which constricts blood vessels and increases blood pressure. By combining these two medications, Arnipin helps improve symptoms and outcomes in patients with heart failure.

Side Effects

Common side effects may include low blood pressure, dizziness, cough, and increased levels of potassium in the blood. These side effects are usually mild and temporary. However, if you experience any severe or persistent side effects, such as difficulty breathing, swelling of the face or throat, or chest pain, seek immediate medical attention.

Drug Interactions

inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements. Certain medications may interact with Arnipin and affect its effectiveness or increase the risk of side effects. Some common drug interactions include other medications that lower blood pressure, potassium-sparing diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Your healthcare provider will consider these interactions and adjust your treatment accordingly.

Precautions

Before starting Arnipin, inform your healthcare provider about any known allergies or medical conditions you have, especially kidney or liver problems. Avoid using Arnipin if you are pregnant or planning to become pregnant, as it may cause harm to the developing fetus. Additionally, it is not recommended during breastfeeding. Arnipin may also interact with certain medications, including other ARBs, and should be used with caution in patients with a history of angioedema.

Storage

Arnipin should be stored at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of reach of children.

Patient Tips

• Take Arnipin exactly as prescribed by your healthcare provider.
• Do not stop taking the medication without consulting your healthcare provider first.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• attend regular follow-up appointments with your healthcare provider to monitor your response to the medication.
• If you have any questions or concerns about Arnipin, consult your healthcare provider or pharmacist for further information.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Valsartan: medicine to treat high blood pressure and heart failure (NHS UK) [Accessed 30 Jun. 2024] (online) Available at:
• Entresto 15 mg/16 mg granules in capsules for opening (Health Professionals SmPC) Available at:
• Sacubitril and valsartan (Drugs.com) [Accessed 16 Jun. 2024] (online) Available at:
• sacubitril-valsartan tablet (RX) [Accessed 8 Jun. 2024] (online) Available at:
• Valsartan and Sacubitril (MedlinePlus) [Accessed 17 Jun. 2024] (online) Available at:
• Pontremoli R, Borghi C, Perrone Filardi P. Renal protection in chronic heart failure: focus on sacubitril/valsartan. Eur Heart J Cardiovasc Pharmacother. 2021 Sep 21;7(5):445-452. doi: 10.1093/ehjcvp/pvab030. [Accessed 10 Jun. 2024] Available at: