Aronem 1000mg/1000mg Injection

Introduction

Aronem is a medication containing the active ingredients Imipenem and Cilastatin. It is used to treat serious infections caused by susceptible strains of bacteria.

Uses

Aronem is prescribed for the treatment of a wide range of infections, including intra-abdominal infections, skin and skin structure infections, urinary tract infections, and lower respiratory tract infections.

Dosage and Administration

The dosage and administration of Aronem should be determined by a healthcare professional based on the severity of the infection, the patient’s renal function, and the specific bacterial susceptibility. It is typically administered intravenously over a period of 20 to 40 minutes.

Mechanism of Action

Imipenem in Aronem inhibits bacterial cell wall synthesis, leading to cell death. Cilastatin, on the other hand, prevents the inactivation of imipenem by renal dehydropeptidase-I, thereby prolonging its antibacterial activity.

Side Effects

Common side effects of Aronem may include nausea, vomiting, diarrhea, and injection site reactions. Serious side effects such as severe allergic reactions, seizures, and Clostridium difficile-associated diarrhea may occur. Patients should seek immediate medical attention if any serious side effects are experienced.

Drug Interactions

Aronem may interact with valproic acid, leading to decreased levels of valproic acid and potential loss of seizure control. Concomitant use with probenecid may increase and prolong the serum levels of imipenem and cilastatin.

Precautions

Patients with a history of hypersensitivity to beta-lactams should exercise caution when using Aronem. Inform the healthcare provider about all current medications, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

Storage

Aronem should be stored at controlled room temperature between 20°C to 25°C (68°F to 77°F). It should be protected from light and kept out of the reach of children.

Patient Tips

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Primaxin IV 500 mg/500 mg powder for solution for infusion (Health Professionals SmPC) Available at:
• Imipenem and cilastatin (Drugs.com) [Accessed 24 Jun. 2024] (online) Available at:
• imipenem-cilastatin sodium vial (RX) [Accessed 29 Jun. 2024] (online) Available at:
• Imipenem, Cilastatin, and Relebactam Injection (MedlinePlus) [Accessed 24 Jun. 2024] (online) Available at:
• Titov I, Wunderink RG, Roquilly A, Rodríguez Gonzalez D, David-Wang A, Boucher HW, Kaye KS, Losada MC, Du J, Tipping R, Rizk ML, Patel M, Brown ML, Young K, Kartsonis NA, Butterton JR, Paschke A, Chen LF. A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study). Clin Infect Dis. 2021 Dec 6;73(11):e4539-e4548. doi: 10.1093/cid/ciaa803. [Accessed 13 Jun. 2024] Available at: