Avadase MR Tablet

Introduction

Avadase MR is a prescription medication that contains three active ingredients: Diclofenac, Serratiopeptidase, and Tizanidine. It is commonly used to provide relief from pain and inflammation associated with various conditions.

Uses

Avadase MR is prescribed to treat a range of conditions, including:

• Musculoskeletal disorders: It helps reduce pain, swelling, and inflammation associated with conditions like arthritis, sprains, strains, and muscle spasms.
• Post-operative pain: It can be used to manage pain after surgical procedures.
• Inflammatory conditions: It may be prescribed to alleviate symptoms of conditions like tendonitis and bursitis.

Dosage and Administration

The dosage of Avadase MR should be determined by your healthcare professional based on your specific condition and medical history. Follow their instructions carefully. The medication is typically taken orally with water.

Mechanism of Action

Diclofenac, one of the active ingredients in Avadase MR, belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of certain chemicals in the body that cause pain and inflammation.

Serratiopeptidase is an enzyme that helps reduce swelling by breaking down proteins that contribute to inflammation.

Tizanidine is a muscle relaxant that works by blocking certain nerve signals in the spinal cord, leading to muscle relaxation and pain relief.

Side Effects

Common side effects may include:

• Upset stomach
• Headache
• Dizziness
• Skin rash

In some cases, more serious side effects may occur. If you experience any of the following, seek medical attention immediately:

• Allergic reactions such as difficulty breathing, swelling of the face or throat, or hives
• Severe stomach pain or black, tarry stools
• Unusual bleeding or bruising
• Yellowing of the skin or eyes (jaundice)

Drug Interactions

Avadase MR may interact with other medications, including:

• Blood thinners: It may increase the risk of bleeding when taken with medications such as warfarin or aspirin.
• Antihypertensive medications: It may enhance the blood pressure-lowering effects of these medications.
• Certain antibiotics: It may affect the effectiveness of certain antibiotics, such as ciprofloxacin.

Inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential interactions.

Precautions

Before taking Avadase MR, discuss your medical history and any existing conditions with your healthcare professional. Here are some important precautions to consider:

• Allergies: Inform your healthcare professional if you have any known allergies, especially to NSAIDs or other medications.
• Stomach ulcers or bleeding: Avadase MR may increase the risk of stomach ulcers or bleeding, particularly in individuals with a history of these conditions.
• Kidney or liver problems: The medication may require dosage adjustments in individuals with impaired kidney or liver function.
• Pregnancy and breastfeeding: Inform your healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding, as the medication may not be suitable in these situations.

Storage

Avadase MR should be stored in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not use the medication after the expiration date printed on the packaging.

Patient Tips

• Take the medication exactly as prescribed by your healthcare professional.
• If you experience any side effects or have concerns, consult your healthcare professional.
• Do not take the medication for longer than prescribed without consulting your healthcare professional.
• Inform your healthcare professional about any other medications or supplements you are taking to avoid potential interactions.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Diclofenac: a non-steroidal anti-inflammatory drug (NSAID) for pain and swelling (NHS UK) [Accessed 0 Jun. 2024] (online) Available at:
• Diclofenac 2.32% gel (Health Professionals SmPC) Available at:
• Diclofenac (Drugs.com) [Accessed 28 Jun. 2024] (online) Available at:
• aleve (diclofenac) 1 % topical gel non-steroidal anti-inflammatory agents (nsaid) (OTC) [Accessed 20 Jun. 2024] (online) Available at:
• Diclofenac Topical (arthritis pain) [Accessed 5 Jun. 2024] (online) Available at:
• Hamed R, Mahmoud NN, Alnadi SH, Alkilani AZ, Hussein G. Diclofenac diethylamine nanosystems-loaded bigels for topical delivery: development, rheological characterization, and release studies. Drug Dev Ind Pharm. 2020 Oct;46(10):1705-1715. doi: 10.1080/03639045.2020.1820038. Epub 2020 Sep 18. [Accessed 23 Jun. 2024] Available at: