Introduction
Avazide MF is a prescription medication that combines two active ingredients: Gliclazide and Metformin. It is commonly used to manage type 2 diabetes mellitus. Gliclazide belongs to a class of medications called sulfonylureas, while Metformin is classified as a biguanide.
Uses
Avazide MF is primarily prescribed to control blood sugar levels in people with type 2 diabetes. It helps improve insulin secretion from the pancreas and enhances insulin sensitivity in the body. This medication is often used as part of a comprehensive treatment plan that includes diet, exercise, and weight management.
Dosage and Administration
The dosage of Avazide MF may vary depending on individual needs and medical condition. Follow your healthcare provider’s instructions regarding the prescribed dose. Typically, the initial recommended dose is one tablet taken once daily with a meal. The extended-release formulation allows for a slow release of the medication throughout the day. Swallow the tablet whole with water, without crushing or chewing it.
Mechanism of Action
Avazide MF works by increasing the release of insulin from the pancreas and reducing the amount of glucose produced by the liver. Gliclazide stimulates the beta cells in the pancreas to release insulin, which helps lower blood sugar levels. Metformin primarily works by reducing the production of glucose in the liver and improving the body’s response to insulin. Together, these mechanisms of action help regulate blood sugar levels in individuals with type 2 diabetes.
Side Effects
Common side effects may include nausea, vomiting, diarrhea, stomach upset, and headache. These side effects are usually temporary and tend to improve over time. However, if they persist or become bothersome, consult your healthcare provider.
In rare cases, Avazide MF may cause more serious side effects. These can include a decrease in blood sugar levels (hypoglycemia), lactic acidosis (a buildup of lactic acid in the body), and allergic reactions. If you experience symptoms such as dizziness, confusion, excessive sweating, rapid heartbeat, or difficulty breathing, seek immediate medical attention.
Drug Interactions
inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products. Certain medications may interact with Avazide MF and affect its effectiveness or increase the risk of side effects. Some examples of common drug interactions include:
- Beta-blockers: These medications may mask the symptoms of low blood sugar and potentially worsen blood sugar control.
- Diuretics: They may increase the risk of lactic acidosis when used together with Metformin.
- Oral contraceptives: They may affect blood sugar control and require dosage adjustments.
Always consult your healthcare provider before starting or stopping any medications while taking Avazide MF.
Precautions
Before taking Avazide MF, inform your healthcare provider about any existing medical conditions or allergies you may have. This medication may not be suitable for everyone, and precautions should be taken in certain situations, such as:
- Allergy to sulfonylureas or biguanides
- Severe kidney or liver disease
- Diabetic ketoacidosis (a serious complication of diabetes)
- Pregnancy or breastfeeding
Additionally, Avazide MF may interact with certain substances, such as alcohol. Avoid excessive alcohol consumption while taking this medication.
Storage
Avazide MF should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.
Patient Tips
Here are some tips to help you make the most of your treatment with Avazide MF:
- Take the medication as directed by your healthcare provider. Do not change the dose or stop taking it without consulting your doctor.
- Follow a healthy diet and exercise regularly to support your diabetes management.
- Monitor your blood sugar levels regularly and keep a log of your readings.
- Keep a source of fast-acting sugar, such as glucose tablets or juice, available in case of low blood sugar episodes.
- Attend regular check-ups with your healthcare provider to monitor your progress and make any necessary adjustments to your treatment plan.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Gliclazide: a medicine to treat type 2 diabetes (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
- Dacadis MR 30mg Modified Release Tablets (Health Professionals SmPC) Available at:
- Gliclazide (International database) (Drugs.com) [Accessed 30 Jun. 2024] (online) Available at:
- metformin (RX) [Accessed 21 Jun. 2024] (online) Available at:
- Oral hypoglycemics overdose (MedlinePlus) [Accessed 9 Jun. 2024] (online) Available at:
- Tomlinson B, Li YH, Chan P. Evaluating gliclazide for the treatment of type 2 diabetes mellitus. Expert Opin Pharmacother. 2022 Dec;23(17):1869-1877. doi: 10.1080/14656566.2022.2141108. Epub 2022 Nov 10. [Accessed 21 Jun. 2024] Available at:
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