Bemzire EZ 180mg/10mg Tablet

Introduction

Bemzire EZ is a prescription medication that combines two active ingredients: Bempedoic acid and Ezetimibe. It is commonly used to manage high cholesterol levels in patients who are at risk of cardiovascular disease.

Uses

Bemzire EZ is primarily prescribed to lower cholesterol levels in patients with hypercholesterolemia or mixed dyslipidemia. It is used as an adjunct to diet and lifestyle modifications when these measures alone are not sufficient to control cholesterol.

Dosage and Administration

The recommended dosage of Bemzire EZ is one tablet taken orally once daily, with or without food. Follow your healthcare provider’s instructions regarding the dosage and duration of treatment. Swallow the tablet whole, without crushing or chewing it.

Mechanism of Action

Bempedoic acid, one of the active ingredients in Bemzire EZ, works by inhibiting an enzyme called ATP citrate lyase, which plays a role in cholesterol synthesis in the liver. By inhibiting this enzyme, it reduces the production of cholesterol in the body.

Ezetimibe, the other active ingredient, works by inhibiting the absorption of cholesterol from the intestine. It blocks a protein called Niemann-Pick C1-Like 1 (NPC1L1), which is responsible for cholesterol uptake from the diet. As a result, less cholesterol is absorbed into the bloodstream.

Together, these two mechanisms of action help to lower cholesterol levels in the body.

Side Effects

Common side effects may include headache, muscle pain, diarrhea, and nasopharyngitis (inflammation of the throat and nasal passages). These side effects are usually mild and temporary.

In rare cases, more serious side effects such as liver problems, muscle damage, or allergic reactions may occur. If you experience any severe or persistent side effects, seek medical attention immediately.

Drug Interactions

Bemzire EZ may interact with certain medications, including cyclosporine, gemfibrozil, and fibrates. These interactions can affect the effectiveness or safety of both Bemzire EZ and the other medications. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, before starting Bemzire EZ.

Precautions

Before taking Bemzire EZ, inform your healthcare provider about any medical conditions you have, especially liver disease or any allergies. This medication may not be suitable for everyone, and your healthcare provider will assess the risks and benefits before prescribing it to you.

Bemzire EZ should not be taken by individuals with active liver disease or unexplained persistent elevations of serum transaminases. It is also contraindicated in pregnant and breastfeeding women.

Storage

Bemzire EZ should be stored at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Do not use the medication after the expiration date printed on the packaging.

Patient Tips

• Follow a healthy diet and exercise regularly while taking Bemzire EZ to achieve the best results in managing your cholesterol levels.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• attend regular follow-up appointments with your healthcare provider to monitor your cholesterol levels and assess the effectiveness of the medication.
• If you have any concerns or questions about Bemzire EZ, don’t hesitate to reach out to your healthcare provider for clarification. They are best suited to address any specific concerns related to your medical condition and treatment plan.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Isovaleric acidaemia (NHS UK) [Accessed 3 Jun. 2024] (online) Available at:
• Nilemdo 180mg film-coated tablets (Health Professionals SmPC) Available at:
• ATP Ignite Side Effects: Common, Severe, Long Term (Drugs.com) [Accessed 19 Jun. 2024] (online) Available at:
• nexletol 180 mg tablet antihyperlipidemic – atp-citrate lyase (acly) inhibitor (RX) [Accessed 18 Jun. 2024] (online) Available at:
• ABCC9 gene (MedlinePlus) [Accessed 16 Jun. 2024] (online) Available at:
• Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. doi: 10.1007/s11302-012-9305-8. Epub 2012 Apr 12. [Accessed 2 Jun. 2024] Available at: