Introduction
C Guan is a prescription medication that contains the active ingredient Proguanil. It is primarily used for the prevention and treatment of malaria.
Uses
C Guan is prescribed to prevent malaria in individuals traveling to areas where the disease is prevalent. It is also used for the treatment of uncomplicated malaria caused by Plasmodium falciparum, a type of parasite that is transmitted through mosquito bites.
Dosage and Administration
The recommended dosage of C Guan for malaria prevention and treatment may vary depending on factors such as the individual’s age, weight, and the specific type of malaria being treated. Follow the instructions provided by your healthcare professional or the medication label.
C Guan is usually taken once daily, with or without food. For prevention, it is typically started one to two days before entering a malaria-endemic area and continued for four weeks after leaving the area. For treatment, the duration of therapy may vary but is generally for a period of seven to fourteen days.
Mechanism of Action
Proguanil, the active ingredient in C Guan, works by interfering with the growth and reproduction of the malaria parasite. It inhibits the synthesis of DNA and RNA in the parasite, thereby preventing its survival and multiplication.
Side Effects
Common side effects may include nausea, vomiting, stomach pain, diarrhea, headache, and dizziness. These side effects are usually mild and temporary.
In some cases, C Guan can cause serious side effects that require immediate medical attention. These may include severe allergic reactions, difficulty breathing, chest pain, irregular heartbeat, and signs of liver problems such as yellowing of the skin or eyes, dark urine, or persistent nausea. If you experience any of these serious side effects, seek medical help right away.
Drug Interactions
C Guan may interact with certain medications, including antacids that contain aluminum, calcium or magnesium, as well as medications that reduce stomach acid. Inform your healthcare professional about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
Precautions
Before taking C Guan, inform your healthcare professional about any allergies you may have, as well as your medical history, especially if you have kidney or liver problems. This medication should be used with caution in individuals with certain genetic conditions, such as glucose-6-phosphate dehydrogenase deficiency.
C Guan should not be used by pregnant women, as it may cause harm to the developing fetus. It is also not recommended for use in breastfeeding women, as it may pass into breast milk.
Storage
Patient Tips
- Take C Guan exactly as prescribed by your healthcare professional.
- If you are traveling to a malaria-endemic area, start taking C Guan before you leave and continue taking it for the recommended duration after you return.
- If you experience any unusual or persistent side effects while taking C Guan, contact your healthcare professional.
- Remember to use additional protective measures, such as insect repellents and bed nets, to reduce the risk of mosquito bites and prevent malaria transmission.
- If you miss a dose of C Guan, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Atovaquone/Proguanil Hydrochloride 250 mg/100 mg film-coated tablets (Health Professionals SmPC) Available at:
- Atovaquone / Proguanil Dosage Guide + Max Dose, Adjustments (Drugs.com) [Accessed 25 Jun. 2024] (online) Available at:
- atovaquone-proguanil hcl (RX) [Accessed 15 Jun. 2024] (online) Available at:
- Atovaquone and Proguanil (MedlinePlus) [Accessed 21 Jun. 2024] (online) Available at:
- Fleming AF. Proguanil. Lancet. 1989 Feb 25;1(8635):439. doi: 10.1016/s0140-6736(89)90034-2. [Accessed 10 Jun. 2024] Available at:
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