Ceftrochem-TZ Injection

Introduction

Ceftrochem-TZ is a prescription medication that contains two active ingredients: Ceftriaxone and Tazobactam. Ceftriaxone is a broad-spectrum antibiotic, while Tazobactam is a beta-lactamase inhibitor. This combination medication is commonly used to treat certain bacterial infections.

Uses

Ceftrochem-TZ is primarily prescribed for the treatment of moderate to severe bacterial infections caused by susceptible organisms. It is commonly used to treat infections of the respiratory tract, urinary tract, skin and soft tissues, and intra-abdominal infections.

Dosage and Administration

Ceftrochem-TZ should be administered under the supervision of a healthcare professional. The dosage and duration of treatment will vary depending on the severity of the infection and the patient’s individual factors.

is typically given intravenously (IV) or intramuscularly (IM). The exact dose and frequency of administration will be determined by the healthcare provider based on the specific needs of the patient.

Complete the full course of treatment as prescribed by the healthcare provider, even if symptoms improve before the medication is finished.

Mechanism of Action

Ceftriaxone, one of the active ingredients in Ceftrochem-TZ, works by inhibiting the synthesis of bacterial cell walls. It does this by binding to specific proteins in the bacterial cell wall, leading to the disruption of cell wall formation and ultimately causing the bacteria to die.

Tazobactam, the other active ingredient, is a beta-lactamase inhibitor. It works by preventing certain bacteria from producing enzymes called beta-lactamases, which can inactivate antibiotics such as Ceftriaxone. By inhibiting beta-lactamases, Tazobactam enhances the effectiveness of Ceftriaxone against susceptible bacteria.

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Headache
• Skin rash

If any of these side effects persist or worsen, inform your healthcare provider.

Serious side effects are rare but can occur. These may include:

• Allergic reactions, such as hives, itching, or difficulty breathing
• Severe diarrhea or abdominal pain
• Seizures
• Yellowing of the skin or eyes (jaundice)

If you experience any serious side effects, seek immediate medical attention.

Drug Interactions

Ceftrochem-TZ may interact with other medications, including:

• Probenecid: May increase the concentration of Ceftriaxone in the blood.
• Calcium-containing solutions: Should not be mixed or co-administered with Ceftrochem-TZ as it may form precipitates.
• Other antibiotics or medications that may cause kidney problems: Use with caution and monitor kidney function.

Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, to avoid any potential drug interactions.

Precautions

Before using Ceftrochem-TZ, inform your healthcare provider if you have any allergies or medical conditions, especially:

• Allergy to cephalosporins or beta-lactam antibiotics
• Kidney disease or impaired kidney function
• Liver disease
• Gastrointestinal disease, such as colitis

Ceftrochem-TZ should be used with caution in patients with these conditions.

Storage

Patient Tips

• Follow the dosage and administration instructions provided by your healthcare provider.
• If you miss a dose, contact your healthcare provider for further instructions.
• Drink plenty of fluids while using Ceftrochem-TZ to help prevent dehydration.
• Inform your healthcare provider if you develop any new symptoms or side effects during treatment.
• Do not use Ceftrochem-TZ beyond the expiration date printed on the packaging.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Ceftriaxone 1 g powder for solution for injection or infusion (Health Professionals SmPC) Available at:
• Ceftriaxone injection (Drugs.com) [Accessed 22 Jun. 2024] (online) Available at:
• ceftriaxone (RX) [Accessed 4 Jun. 2024] (online) Available at:
• Ceftriaxone Injection (MedlinePlus) [Accessed 22 Jun. 2024] (online) Available at:
• Gupta AK, Wadhwa A, Anand NK. Ceftriaxone. Indian Pediatr. 1990 Apr;27(4):381-4. [Accessed 3 Jun. 2024] Available at: