Cladrim 10mg Injection

Introduction

Cladrim is a medication that contains the active ingredient Cladribine. It is available in injection form and is used for the treatment of certain types of cancer, including hairy cell leukemia. Cladrim is a brand name for this medication.

Uses

Cladrim is prescribed to treat hairy cell leukemia, a rare type of cancer that affects the blood and bone marrow. It is used when other treatments have not been effective or are not suitable. It works by interfering with the growth and multiplication of cancer cells, helping to slow down the progression of the disease.

Dosage and Administration

Cladrim is administered by a healthcare professional. The dosage and schedule will be determined by your doctor based on various factors, including your overall health and the severity of your condition. The medication is typically given as a slow intravenous infusion over a period of several hours. The exact dosage and duration of treatment will be determined by your doctor.

Mechanism of Action

Cladribine, the active ingredient in Cladrim, works by interfering with the DNA synthesis in cancer cells. It is a cytotoxic agent that inhibits the growth and division of cancer cells, ultimately leading to their destruction. By targeting and killing cancer cells, Cladribine helps to reduce the size of tumors and slow down the progression of the disease.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, fever, fatigue, and headache. These side effects are usually mild and temporary. However, if they persist or become severe, inform your doctor.

Serious side effects of Cladrim may include decreased blood cell counts, increased risk of infections, bleeding problems, and liver toxicity. Contact your doctor immediately if you experience any unusual symptoms such as persistent fever, unexplained bruising or bleeding, yellowing of the skin or eyes, or signs of infection such as sore throat or cough.

Drug Interactions

inform your doctor about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Some medications may interact with Cladrim and affect its effectiveness or increase the risk of side effects. Examples of drugs that may interact with Cladribine include immunosuppressants, live vaccines, and certain antiviral medications. Your doctor will carefully consider these potential interactions when prescribing Cladrim.

Precautions

Before starting treatment with Cladrim, inform your doctor about any medical conditions you have, especially if you have a history of kidney or liver problems, immune system disorders, or ongoing infections. Cladrim should not be used during pregnancy or breastfeeding, as it may harm the developing fetus or newborn.

Cladrim may also interact with other medications or substances, such as alcohol or certain herbal supplements. Follow your doctor’s instructions and avoid any potential interactions that could affect the safety and effectiveness of the medication.

Storage

Cladrim should be stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). Protect the medication from light and keep it out of the reach of children. Do not freeze the medication, and discard any unused portion after the recommended duration of treatment.

Patient Tips

• Follow all instructions provided by your healthcare provider regarding the administration of Cladrim.
• Report any side effects or unusual symptoms to your doctor promptly.
• Keep all scheduled appointments for blood tests and follow-up visits.
• Store the medication properly in the refrigerator, and do not use it if it has expired or if the packaging is damaged.
• Avoid contact with people who have infections while receiving treatment with Cladrim.
• Inform your doctor about any other medications or supplements you are taking before starting treatment with Cladrim.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Mastocytosis – Treatment (NHS UK) [Accessed 30 Jun. 2024] (online) Available at:
• Leustat injection (Health Professionals SmPC) Available at:
• Cladribine (Drugs.com) [Accessed 10 Jun. 2024] (online) Available at:
• cladribine (multiple sclerosis) 10 mg tablet (RX) [Accessed 21 Jun. 2024] (online) Available at:
• Cladribine (MedlinePlus) [Accessed 13 Jun. 2024] (online) Available at:
• Chihara D, Arons E, Stetler-Stevenson M, Yuan CM, Wang HW, Zhou H, Raffeld M, Xi L, Steinberg SM, Feurtado J, James L, Wilson W, Braylan RC, Calvo KR, Maric I, Dulau-Florea A, Kreitman RJ. Randomized Phase II Study of First-Line Cladribine With Concurrent or Delayed Rituximab in Patients With Hairy Cell Leukemia. J Clin Oncol. 2020 May 10;38(14):1527-1538. doi: 10.1200/JCO.19.02250. Epub 2020 Feb 28. [Accessed 13 Jun. 2024] Available at: