Cleft 10 Tablet

Introduction

Cleft is a prescription medication that contains the active ingredient Leflunomide. It is available under the brand name Cleft. This medication is primarily used for the treatment of rheumatoid arthritis, a chronic inflammatory condition that affects the joints.

Uses

Cleft is prescribed to manage the signs and symptoms of rheumatoid arthritis. It helps to reduce joint pain, swelling, and stiffness, and improves physical function in individuals with this condition. Rheumatoid arthritis is an autoimmune disease where the body’s immune system mistakenly attacks the joints, leading to inflammation and damage.

Dosage and Administration

The dosage of Cleft may vary depending on individual factors such as the severity of rheumatoid arthritis and the patient’s response to treatment. Follow the instructions provided by your healthcare provider. Generally, the recommended starting dose of Cleft is 100 mg once daily for the first three days, followed by a maintenance dose of 20 mg to 30 mg once daily. Your healthcare provider will determine the most appropriate dose for you.

Cleft should be taken orally with or without food. Swallow the tablet whole with a glass of water, and do not crush or chew it. Take the medication regularly as prescribed for optimal effectiveness.

Mechanism of Action

The active ingredient in Cleft, Leflunomide, works by suppressing the activity of certain immune cells involved in the inflammation process in rheumatoid arthritis. It inhibits an enzyme called dihydroorotate dehydrogenase, which is important for the production of DNA in rapidly dividing cells. By reducing the proliferation of these immune cells, Cleft helps to control the autoimmune response and alleviate the symptoms of rheumatoid arthritis.

Side Effects

Common side effects include diarrhea, nausea, stomach pain, and headache. These side effects are usually mild and temporary. However, if they persist or become bothersome. Consult your healthcare provider.

Serious side effects may occur in rare cases and require immediate medical attention. These include liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea and vomiting. Cleft may also affect the bone marrow, leading to a decrease in blood cell counts. Inform your healthcare provider if you experience unusual bleeding or bruising, or signs of infection such as fever or sore throat.

If you experience any severe or persistent side effects while taking Cleft, seek medical attention right away.

Drug Interactions

Cleft may interact with other medications, including over-the-counter drugs, herbal supplements, and vitamins. Inform your healthcare provider about all the medications you are taking to avoid potential drug interactions. Some medications that may interact with Cleft include warfarin, methotrexate, and rifampin. These interactions can affect the effectiveness or safety of both medications. Your healthcare provider will monitor your treatment closely if you are taking any of these medications together with Cleft.

Precautions

Before starting Cleft, inform your healthcare provider about any medical conditions you have, especially liver or kidney problems. This medication may not be suitable for individuals with certain underlying conditions. Disclose any allergies or sensitivities you may have to medications or other substances.

Cleft is contraindicated in pregnant women or those planning to become pregnant, as it may cause harm to the developing fetus. Effective contraception should be used during treatment and for a certain period after stopping the medication. Discuss reliable contraceptive methods with your healthcare provider.

Storage

Cleft should be stored at room temperature, away from moisture and heat. Keep the medication in its original packaging, and out of reach of children and pets. Do not use Cleft beyond its expiration date as indicated on the packaging.

Patient Tips

• Take Cleft exactly as prescribed by your healthcare provider.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take more than the prescribed dose of Cleft, as it will not provide additional benefit and may increase the risk of side effects.
• It may take several weeks for Cleft to show its full effect. Be patient and continue taking the medication as directed.
• Inform your healthcare provider about any new symptoms or side effects you experience while taking Cleft.
• Attend regular follow-up appointments with your healthcare provider to monitor your response to treatment and adjust the dosage if needed.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Arava 10mg Tablets (Health Professionals SmPC) Available at:
• Leflunomide (Drugs.com) [Accessed 19 Jun. 2024] (online) Available at:
• leflunomide (RX) [Accessed 23 Jun. 2024] (online) Available at:
• Leflunomide (MedlinePlus) [Accessed 24 Jun. 2024] (online) Available at:
• Zheng K, Chen Y, Liu S, He C, Yang Y, Wu D, Wang L, Li M, Zeng X, Zhang F. Leflunomide: Traditional immunosuppressant with concurrent antiviral effects. Int J Rheum Dis. 2023 Feb;26(2):195-209. doi: 10.1111/1756-185X.14491. Epub 2022 Nov 13. [Accessed 22 Jun. 2024] Available at: