Introduction
Conape Plus is a prescription medication that contains two active ingredients: Perindopril erbumine and Indapamide. Perindopril erbumine is a medication known as an angiotensin-converting enzyme (ACE) inhibitor, while Indapamide belongs to a class of drugs called thiazide diuretics. This combination medication is commonly prescribed to treat high blood pressure (hypertension).
Uses
Conape Plus is primarily used to lower blood pressure in individuals with hypertension. By reducing blood pressure, it helps to prevent complications such as heart attacks, strokes, and kidney problems. This medication may be prescribed as part of a comprehensive treatment plan that includes lifestyle changes such as a healthy diet, regular exercise, and smoking cessation.
Dosage and Administration
The dosage of Conape Plus may vary depending on individual factors such as the severity of hypertension and the patient’s response to treatment. Follow the instructions provided by your healthcare professional and take the medication exactly as prescribed. Typically, the recommended starting dose is one tablet taken once daily, preferably in the morning with or without food. Your healthcare professional may adjust the dosage based on your blood pressure response.
Mechanism of Action
Perindopril erbumine, one of the active ingredients in Conape Plus, works by inhibiting the activity of an enzyme called angiotensin-converting enzyme. This enzyme is involved in the production of a hormone called angiotensin II, which causes blood vessels to narrow and blood pressure to rise. By inhibiting this enzyme, Perindopril erbumine helps to relax and widen the blood vessels, thereby lowering blood pressure.
Indapamide, the other active ingredient in Conape Plus, works by increasing the excretion of salt and water from the body, leading to a decrease in blood volume. This diuretic effect helps to reduce the amount of fluid in the blood vessels, which in turn lowers blood pressure.
Side Effects
Common side effects may include dizziness, headache, fatigue, cough, upset stomach, and indigestion. These side effects are usually mild and temporary. However, if they persist or worsen, consult your healthcare professional.
Serious side effects are rare but may include allergic reactions, severe dizziness, fainting, irregular heartbeat, swelling of the face, lips, tongue, or throat, and signs of kidney problems such as decreased urine output or blood in the urine. If you experience any of these serious side effects, seek immediate medical attention.
Drug Interactions
Conape Plus may interact with certain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), potassium-sparing diuretics, lithium, and certain medications used to treat diabetes. Inform your healthcare professional about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions.
Precautions
Before taking Conape Plus, inform your healthcare professional about any medical conditions you have, especially if you have a history of kidney disease, liver disease, heart disease, diabetes, or electrolyte imbalances. This medication may not be suitable for everyone, and your healthcare professional will assess the potential risks and benefits before prescribing it.
Conape Plus is contraindicated in patients who have a history of angioedema (swelling of the face, lips, tongue, or throat) related to previous ACE inhibitor treatment. It is also not recommended for use during pregnancy or while breastfeeding.
Storage
Conape Plus should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.
Patient Tips
- Take Conape Plus as prescribed by your healthcare professional, even if you feel well. High blood pressure often has no symptoms, so continue taking the medication to keep your blood pressure under control.
- If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
- Avoid excessive alcohol consumption while taking Conape Plus, as it may increase the risk of side effects such as dizziness or lightheadedness.
- If you experience any signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
- Regularly monitor your blood pressure as directed by your healthcare professional and attend all follow-up appointments to ensure the medication is effectively controlling your blood pressure.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Indapamide: a medicine to treat high blood pressure (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
- Coversyl arginine plus 5 mg/1.25 mg Film-coated Tablets (Health Professionals SmPC) Available at:
- Indapamide (Drugs.com) [Accessed 25 Jun. 2024] (online) Available at:
- indapamide (RX) [Accessed 23 Jun. 2024] (online) Available at:
- Indapamide (MedlinePlus) [Accessed 10 Jun. 2024] (online) Available at:
- Aziz S; Abdullah; Rajbhandari S. Not So Innocent Indapamide. J Ayub Med Coll Abbottabad. 2023 Apr-Jun;35(2):324-326. doi: 10.55519/JAMC-02-10426. [Accessed 1 Jun. 2024] Available at:
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