Introduction
Crisavoc is a prescription medication that contains the active ingredient Isavuconazole. It is available in the form of a solution and is used to treat certain fungal infections.
Uses
Crisavoc is primarily prescribed to treat invasive aspergillosis and invasive mucormycosis, which are serious fungal infections that can affect various parts of the body, including the lungs, sinuses, and brain. It may also be used to treat other fungal infections as determined by your healthcare provider.
Dosage and Administration
The dosage of Crisavoc can vary depending on the specific fungal infection being treated, as well as individual factors such as age, weight, and overall health. Follow the instructions provided by your healthcare provider or the label on the medication.
Crisavoc is usually taken by mouth, with or without food. Take the medication at the same time(s) each day to maintain a consistent level of the drug in your body. Do not skip doses or stop taking the medication without consulting your healthcare provider.
Mechanism of Action
Isavuconazole, the active ingredient in Crisavoc, belongs to a class of medications called triazole antifungals. It works by interfering with the growth and reproduction of the fungal cells, ultimately leading to their death. Isavuconazole specifically targets the enzyme responsible for producing ergosterol, a key component of the fungal cell membrane. By inhibiting this enzyme, Isavuconazole disrupts the integrity of the fungal cell membrane, weakening and ultimately destroying the fungal cells.
Side Effects
Common side effects may include nausea, vomiting, diarrhea, headache, and changes in liver function tests. These side effects are generally mild and temporary.
However, some individuals may experience more serious side effects, such as allergic reactions, liver problems, or abnormal heart rhythm. If you experience any severe or persistent side effects, seek medical attention immediately.
Drug Interactions
Crisavoc may interact with other medications, including certain antifungals, antibiotics, and medications that affect liver enzymes. These interactions can potentially increase the risk of side effects or reduce the effectiveness of either medication. Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products.
Precautions
Before taking Crisavoc, inform your healthcare provider about any allergies you may have, as well as any other medical conditions you have, such as liver or kidney problems. This medication may not be suitable for everyone, and your healthcare provider can help determine if it is the right choice for you.
Crisavoc may interact with other medications or substances, including certain antifungals, antibiotics, and medications that affect liver enzymes. Follow your healthcare provider’s instructions and avoid any potential interactions.
Storage
Patient Tips
- Take Crisavoc exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without consulting your healthcare provider.
- If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- complete the full course of treatment, even if you start feeling better before the treatment is completed.
- If you have any questions or concerns about Crisavoc, its uses, or potential side effects, do not hesitate to consult your healthcare provider.
- Follow good hygiene practices to help prevent the spread of fungal infections, such as washing your hands regularly, keeping your living environment clean, and avoiding close contact with individuals who have active infections.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Isavuconazole use while Breastfeeding (Drugs.com) [Accessed 6 Jun. 2024] (online) Available at:
- Mucormycosis (MedlinePlus) [Accessed 1 Jun. 2024] (online) Available at:
- Maertens JA, Raad II, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, Bow EJ, Rahav G, Neofytos D, Aoun M, Baddley JW, Giladi M, Heinz WJ, Herbrecht R, Hope W, Karthaus M, Lee DG, Lortholary O, Morrison VA, Oren I, Selleslag D, Shoham S, Thompson GR 3rd, Lee M, Maher RM, Schmitt-Hoffmann AH, Zeiher B, Ullmann AJ. Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016 Feb 20;387(10020):760-9. doi: 10.1016/S0140-6736(15)01159-9. Epub 2015 Dec 10. [Accessed 29 Jun. 2024] Available at:
- Kullberg BJ, Viscoli C, Pappas PG, Vazquez J, Ostrosky-Zeichner L, Rotstein C, Sobel JD, Herbrecht R, Rahav G, Jaruratanasirikul S, Chetchotisakd P, Van Wijngaerden E, De Waele J, Lademacher C, Engelhardt M, Kovanda L, Croos-Dabrera R, Fredericks C, Thompson GR. Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial. Clin Infect Dis. 2019 May 30;68(12):1981-1989. doi: 10.1093/cid/ciy827. [Accessed 10 Jun. 2024] Available at:
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