Dalimune 50mg Tablet

Introduction

Dalimune is a prescription medication that contains the active ingredient Dolutegravir. It is available under the brand name Dalimune. This medication is primarily used for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 30 kilograms (kg). It is an antiretroviral medication that helps to control the replication of the human immunodeficiency virus (HIV) in the body.

Uses

Dalimune is prescribed to manage HIV-1 infection in adults and pediatric patients weighing at least 30 kg. It is used in combination with other antiretroviral agents as part of an effective therapy regimen. This medication helps to reduce the amount of HIV in the blood and improves the immune system’s ability to fight off infections.

Dosage and Administration

The dosage of Dalimune may vary depending on the individual’s age, weight, and the specific treatment plan prescribed by the healthcare provider. Follow the instructions provided by your doctor or pharmacist.

Dalimune is usually taken once daily with or without food. It is recommended to swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless instructed by your healthcare provider.

Take this medication regularly and at the same time each day to achieve the best results. Do not skip doses or stop taking the medication without consulting your doctor.

Mechanism of Action

Dolutegravir, the active ingredient in Dalimune, belongs to a class of medications called integrase strand transfer inhibitors (INSTIs). It works by blocking the action of an enzyme called integrase, which is necessary for the replication of the HIV virus. By inhibiting this enzyme, Dolutegravir helps to prevent the integration of the viral DNA into the DNA of the host immune cells, thereby reducing the viral load and slowing down the progression of HIV infection.

Side Effects

be aware of the possible side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common side effects may include:

• Headache
• Nausea
• Diarrhea
• Insomnia
• Fatigue

Serious side effects are rare but can occur. These may include:

• Severe allergic reactions (e.g., rash, itching, swelling)
• Liver problems (e.g., yellowing of the skin or eyes, dark urine, abdominal pain)
• Mood changes or depression
• Severe skin reactions (e.g., Stevens-Johnson syndrome)
• Changes in body fat distribution

If you experience any of these serious side effects or any other unusual symptoms, seek immediate medical attention.

Drug Interactions

Dalimune may interact with other medications, supplements, or substances. Inform your healthcare provider about all the medications you are currently taking, including prescription medications, over-the-counter drugs, and herbal supplements. Some common drug interactions may include:

• Medications that induce or inhibit certain liver enzymes, such as rifampin or ritonavir, may affect the blood levels of Dolutegravir.
• Antacids or mineral supplements containing magnesium, aluminum, or calcium may reduce the absorption of Dolutegravir. It is recommended to take Dalimune at least 2 hours before or 6 hours after taking these products.

Consult your healthcare provider or pharmacist for a complete list of potential drug interactions.

Precautions

Before starting Dalimune, discuss your medical history and any other medications you are taking with your healthcare provider. It is particularly important to inform your doctor if you have:

• Liver problems
• Kidney problems
• History of depression or other mental health conditions
• Allergies to any medications

Dalimune may not be suitable for everyone. Follow the prescribed dosage and to inform your healthcare provider if you experience any unusual symptoms.

Storage

Dalimune should be stored at room temperature, away from excess heat and moisture. Keep the medication in its original packaging and out of reach of children. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Dalimune as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without consulting your doctor.
• maintain a healthy lifestyle, including a balanced diet and regular exercise, while taking this medication.
• If you miss a dose, take it as soon as you remember. However, if it is already close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Use effective contraception methods to prevent pregnancy while taking Dalimune, as it may cause harm to an unborn baby.
• If you are experiencing any side effects or have any concerns, discuss them with your healthcare provider. They can provide guidance and support throughout your treatment.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Dovato 50 mg/300 mg film-coated tablets (Health Professionals SmPC) Available at:
• Dolutegravir (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• abacavir 60 mg-dolutegravir 5 mg-lamivudine 30 mg tablet for oral susp (RX) [Accessed 3 Jun. 2024] (online) Available at:
• Dolutegravir (MedlinePlus) [Accessed 26 Jun. 2024] (online) Available at:
• Loosli T, Hossmann S, Ingle SM, Okhai H, Kusejko K, Mouton J, Bellecave P, van Sighem A, Stecher M, d’Arminio Monforte A, Gill MJ, Sabin CA, Maartens G, Günthard HF, Sterne JAC, Lessells R, Egger M, Kouyos RD. HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis. Lancet HIV. 2023 Nov;10(11):e733-e741. doi: 10.1016/S2352-3018(23)00228-X. Epub 2023 Oct 10. [Accessed 13 Jun. 2024] Available at: