Debrifree Ointment

Introduction

Debrifree is a topical medication that is available both over-the-counter and by prescription. It contains two active ingredients: Papain and Urea. Papain is a proteolytic enzyme derived from papaya fruit, while Urea is a naturally occurring substance that helps to soften and moisturize the skin.

Uses

Debrifree is primarily used for the treatment of various skin conditions, such as calluses, corns, and dry, rough, or scaly skin. It helps to exfoliate and soften the skin, making it easier to remove dead skin cells and promote smoother skin texture.

Dosage and Administration

For adults and children 2 years of age and older, apply a thin layer of Debrifree to the affected area(s) once or twice daily, or as directed by your healthcare provider. Gently massage the ointment into the skin until it is absorbed. Follow the instructions provided by your healthcare provider or the product label.

Mechanism of Action

Papain, one of the active ingredients in Debrifree, works by breaking down the proteins that hold dead skin cells together. This helps to exfoliate the skin and remove the outer layer of dead skin cells, revealing smoother and healthier skin underneath. Urea, on the other hand, has hydrating properties and helps to retain moisture in the skin, preventing dryness and promoting softness.

Side Effects

Common side effects may include mild skin irritation, redness, or itching at the site of application. These side effects are usually temporary and should subside on their own. However, if you experience any persistent or severe side effects, such as blistering, swelling, or signs of an allergic reaction (e.g., rash, hives, difficulty breathing), discontinue use and seek medical attention immediately.

Drug Interactions

Debrifree is generally well-tolerated and has a low risk of interacting with other medications. However, it is always important to inform your healthcare provider or pharmacist about all the medications you are taking, including prescription, over-the-counter, and herbal products, to avoid any potential drug interactions.

Precautions

Before using Debrifree, inform your healthcare provider if you have any known allergies to papain, urea, or any other ingredients in the ointment. Additionally, if you have any open wounds, infections, or broken skin in the area to be treated, it is advisable to consult with your healthcare provider before using this medication. Avoid contact with eyes, mouth, and other mucous membranes.

Storage

Patient Tips

• Wash and dry the affected area(s) before applying the ointment.
• Use a thin layer of the ointment and avoid applying it to healthy skin.
• If you are unsure about how to use Debrifree or have any questions, consult your healthcare provider or pharmacist.
• If your symptoms worsen or do not improve after using the ointment as directed, seek medical advice.
• Avoid prolonged or excessive use of the ointment without consulting your healthcare provider.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Balneum Plus Cream (Health Professionals SmPC) Available at:
• Papain/Urea Topical Dosage Guide + Max Dose, Adjustments (Drugs.com) [Accessed 14 Jun. 2024] (online) Available at:
• benzoyl peroxide-urea gel (RX) [Accessed 8 Jun. 2024] (online) Available at:
• Ullrich S, Nitsche C. SARS-CoV-2 Papain-Like Protease: Structure, Function and Inhibition. Chembiochem. 2022 Oct 6;23(19):e202200327. doi: 10.1002/cbic.202200327. Epub 2022 Sep 8. [Accessed 11 Jun. 2024] Available at: