Definate LF 80mg/480mg Tablet

Introduction

Definate LF is a prescription medication that contains two active ingredients: Artesunate and Lumefantrine. It is commonly used for the treatment of malaria. This medication is available in tablet form and is usually prescribed by healthcare professionals to patients with confirmed cases of malaria.

Uses

Definate LF is primarily used in the treatment of uncomplicated malaria caused by Plasmodium falciparum. It is effective in killing the malaria parasites and reducing the symptoms associated with the infection. This medication should only be used under the guidance and supervision of a healthcare professional.

Dosage and Administration

The dosage of Definate LF may vary depending on the severity of the malaria infection and the patient’s age and weight. Follow the instructions provided by your healthcare professional. Generally, the recommended dose for adults and children weighing over 35 kilograms is one tablet every 8 hours for a total of 3 days. For children weighing between 5 and 35 kilograms, the dosage is based on body weight and may need to be adjusted accordingly. The tablets should be swallowed whole with water, preferably after a meal.

Mechanism of Action

Artesunate and Lumefantrine, the active ingredients in Definate LF, work together to combat malaria. Artesunate acts by interfering with the growth and reproduction of malaria parasites, while Lumefantrine helps to eliminate the remaining parasites from the body. This combination therapy is effective in treating malaria and preventing its recurrence.

Side Effects

Common side effects include headache, dizziness, nausea, vomiting, and diarrhea. These side effects are usually mild and resolve on their own. However, if they persist or become bothersome, consult your healthcare professional.

In some cases, serious side effects may occur, although they are rare. These can include allergic reactions, such as rash, itching, or swelling of the face, lips, or tongue. If you experience any serious side effects, seek immediate medical attention.

Drug Interactions

Definate LF may interact with other medications, including certain antibiotics, anticonvulsants, and antiretroviral drugs. Inform your healthcare professional about all the medications you are currently taking, including prescription, over-the-counter, and herbal products, to avoid any potential drug interactions. Your healthcare professional will be able to guide you on the appropriate use of Definate LF while taking other medications.

Precautions

Before taking Definate LF, inform your healthcare professional about any known allergies or sensitivities to Artesunate, Lumefantrine, or any other medications. This medication may not be suitable for everyone, especially those with certain medical conditions, such as liver or kidney problems. Discuss your medical history with your healthcare professional before starting this treatment.

Definate LF should not be used by pregnant women, as it may cause harm to the unborn baby. Use effective contraception during treatment and for at least one month after stopping the medication.

Storage

Definate LF should be stored in a cool, dry place, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Definate LF exactly as prescribed by your healthcare professional, and complete the full course of treatment, even if you start feeling better before the treatment is complete.
• If you experience any side effects, such as nausea or vomiting, try taking the medication with food to minimize stomach upset.
• avoid alcohol consumption while taking Definate LF, as it may increase the risk of side effects or reduce the effectiveness of the medication.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• If you have any concerns or questions about Definate LF, do not hesitate to consult your healthcare professional. They are best equipped to provide personalized advice and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Artesunate (Drugs.com) [Accessed 28 Jun. 2024] (online) Available at:
• artesunate 110 mg intravenous solution antimalarial drugs (RX) [Accessed 3 Jun. 2024] (online) Available at:
• Malaria (MedlinePlus) [Accessed 29 Jun. 2024] (online) Available at:
• Li ZJ, Dai HQ, Huang XW, Feng J, Deng JH, Wang ZX, Yang XM, Liu YJ, Wu Y, Chen PH, Shi H, Wang JG, Zhou J, Lu GD. Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. Acta Pharmacol Sin. 2021 Feb;42(2):301-310. doi: 10.1038/s41401-020-0478-3. Epub 2020 Jul 22. [Accessed 1 Jun. 2024] Available at: