Estacef-O Oral Suspension

Introduction

Estacef-O is a prescription medication that contains two active ingredients: Cefixime and Ofloxacin. Cefixime is a third-generation cephalosporin antibiotic, while Ofloxacin is a fluoroquinolone antibiotic. This combination medication is primarily used to treat bacterial infections in the respiratory tract, urinary tract, skin, and other areas of the body.

Uses

Estacef-O is commonly prescribed to treat a variety of bacterial infections, including:

• Respiratory tract infections: such as bronchitis, pneumonia, and sinusitis.
• Urinary tract infections: including cystitis and pyelonephritis.
• Skin and soft tissue infections: such as cellulitis and abscesses.
• Sexually transmitted infections: such as gonorrhea.

Note that Estacef-O is only effective against bacterial infections and will not work for viral infections, such as the common cold or flu.

Dosage and Administration

The dosage of Estacef-O may vary depending on the specific infection being treated, the patient’s age, weight, and overall health. Follow the instructions provided by the prescribing healthcare professional. Generally, the recommended dose for adults and children over 12 years of age is 10 ml of the suspension twice daily. For children between 6 months and 12 years of age, the dose is usually based on their body weight. The suspension should be shaken well before each use to ensure proper mixing of the medication.

Mechanism of Action

Estacef-O works by inhibiting the growth and spread of bacteria in the body. Cefixime interferes with the synthesis of bacterial cell walls, weakening and ultimately destroying the bacteria. Ofloxacin, on the other hand, inhibits the activity of certain enzymes in the bacteria, preventing them from reproducing and causing further infection. The combination of these two active ingredients provides a broad-spectrum effect against a wide range of bacteria.

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Stomach pain
• Headache
• Dizziness

note that these side effects are usually mild and temporary. However, if any of these side effects persist or worsen, it is recommended to consult a healthcare professional.

In rare cases, Estacef-O may cause more serious side effects. These can include:

• Allergic reactions: such as rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if any signs of an allergic reaction occur.
• Severe diarrhea: which may be a sign of a bacterial infection called Clostridium difficile-associated diarrhea. Notify a healthcare professional if persistent or severe diarrhea occurs.
• Tendon damage: although rare, some individuals may experience tendonitis or tendon rupture while taking fluoroquinolone antibiotics like Ofloxacin. If you experience any joint pain or swelling, discontinue the medication and seek medical advice.

Drug Interactions

Estacef-O may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some common drug interactions to be aware of include:

• Antacids or sucralfate: These medications may reduce the absorption of Ofloxacin, so it is recommended to take Estacef-O at least 2 hours before or after taking these medications.
• Warfarin or other blood thinners: There is a potential for increased bleeding or changes in blood clotting when taking Estacef-O with these medications. Regular monitoring of blood clotting parameters may be necessary.
• Probenecid: This medication may increase the concentration of Cefixime in the body, potentially leading to higher levels of the antibiotic. Close monitoring is advised when these medications are used together.

This is not an exhaustive list of drug interactions, and other medications may also interact with Estacef-O. Always consult with your healthcare professional for personalized advice.

Precautions

Before taking Estacef-O, inform your healthcare professional about any existing medical conditions or allergies you may have. Additionally, certain precautions should be considered:

• Allergies: If you are allergic to cephalosporin or fluoroquinolone antibiotics, you should not take Estacef-O.
• Pregnancy and breastfeeding: inform your healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding. They will assess the potential risks and benefits before prescribing this medication.
• Liver or kidney problems: Individuals with liver or kidney problems may require adjusted dosages of Estacef-O. Close monitoring by a healthcare professional is advised.
• Photosensitivity: Estacef-O may increase sensitivity to sunlight or UV rays. It is recommended to avoid prolonged sun exposure and use appropriate sun protection measures while taking this medication.

Storage

Estacef-O should be stored at room temperature, away from excessive heat, moisture, and light. Keep the bottle tightly closed when not in use. Store medications out of reach of children and pets.

Patient Tips

• Take the full course: complete the full course of Estacef-O as prescribed by your healthcare professional, even if you start feeling better before finishing the medication. Stopping the medication prematurely may lead to incomplete treatment and the risk of recurrent infection.
• Follow dosage instructions: Take the prescribed dosage at the recommended times. Do not take more or less of the medication without consulting your healthcare professional.
• Take with caution: If you experience any unusual symptoms or side effects while taking Estacef-O, notify your healthcare professional promptly.
• Do not share: Do not share your medication with others, even if they have similar symptoms. Estacef-O is prescribed based on individual needs and medical conditions.
• Complete medical history: Ensure that your healthcare professional is aware of your complete medical history, including any allergies, existing medical conditions, and medications you are currently taking. This information will help them make informed decisions regarding your treatment.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• EXOCIN® 3 mg/ml Eye Drops, Solution. (Health Professionals SmPC) Available at:
• Cefixime (Drugs.com) [Accessed 3 Jun. 2024] (online) Available at:
• cefixime (RX) [Accessed 10 Jun. 2024] (online) Available at:
• Cefixime (MedlinePlus) [Accessed 24 Jun. 2024] (online) Available at:
• Stafylis C, Keith K, Mehta S, Tellalian D, Burian P, Millner C, Klausner JD. Clinical Efficacy of Cefixime for the Treatment of Early Syphilis. Clin Infect Dis. 2021 Sep 7;73(5):907-910. doi: 10.1093/cid/ciab187. [Accessed 26 Jun. 2024] Available at: