FRUMIDE 40MG/5MG TABLET

Introduction

FRUMIDE is a prescription medication that combines two active ingredients: Furosemide and Amiloride. Furosemide is a diuretic that helps the body get rid of excess salt and water, while Amiloride helps the body retain potassium. This medication is primarily used to treat edema (fluid retention) associated with congestive heart failure, liver disease, or kidney disorders. It is available under the brand name FRUMIDE.

Uses

FRUMIDE is prescribed to manage edema (fluid retention) in patients with congestive heart failure, liver disease, or kidney disorders. Edema can cause swelling in various parts of the body, such as the legs, ankles, and abdomen. This medication helps reduce swelling by increasing urine production and removing excess fluid and salt from the body.

Dosage and Administration

• The dosage of FRUMIDE will vary depending on your specific condition and response to treatment. Follow your healthcare provider’s instructions carefully.
• The tablets are usually taken orally with water, with or without food.
• It is recommended to take this medication in the morning to avoid disrupting sleep due to increased urination.
• Do not crush or chew the tablets. Swallow them whole.

Mechanism of Action

FRUMIDE contains two active ingredients with different mechanisms of action. Furosemide works by inhibiting the reabsorption of sodium and chloride in the kidneys, leading to increased urine production. This helps reduce fluid retention. Amiloride, on the other hand, works by preventing the excessive loss of potassium in the urine, which can occur with the use of diuretics.

Side Effects

Common side effects may include:

• Increased urination
• Dizziness or lightheadedness
• Muscle cramps
• Weakness or fatigue

Serious side effects are rare but may include:

• Allergic reactions (rash, itching, swelling)
• Dehydration
• Electrolyte imbalances (low potassium or sodium levels)
• Hearing loss or ringing in the ears

If you experience any serious side effects or have concerns about the side effects you are experiencing, consult your healthcare provider immediately.

Drug Interactions

FRUMIDE may interact with certain medications and substances, including:

• Other diuretics
• Lithium
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Digoxin
• ACE inhibitors

inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting FRUMIDE to avoid any potential interactions.

Precautions

Before taking FRUMIDE, consider the following precautions:

• Inform your healthcare provider if you have any known allergies or sensitivities to Furosemide, Amiloride, or any other medications.
• Discuss your medical history, especially if you have a history of kidney or liver disease, diabetes, gout, or electrolyte imbalances.
• This medication may cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how it affects you.
• stay adequately hydrated while taking FRUMIDE. Drink plenty of fluids, unless otherwise advised by your healthcare provider.
• Avoid excessive exposure to sunlight or artificial UV rays, as this medication may increase your sensitivity to sunlight.

Storage

FRUMIDE should be stored at room temperature, away from moisture and heat. Keep it out of the reach of children and pets. Do not use the medication if it has expired or if you notice any visible signs of deterioration.

Patient Tips

Here are some additional tips to consider while taking FRUMIDE:

• Follow your healthcare provider’s instructions regarding dosage and administration.
• Take the medication at the same time each day to help establish a routine.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• attend regular check-ups with your healthcare provider to monitor your progress and adjust the treatment if needed.
• Inform your healthcare provider if you experience any new or worsening symptoms while taking FRUMIDE.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Furosemide: medicine to treat high blood pressure and oedema (NHS UK) [Accessed 24 Jun. 2024] (online) Available at:
• Amiloride 5mg Tablets (Health Professionals SmPC) Available at:
• Amiloride (Drugs.com) [Accessed 14 Jun. 2024] (online) Available at:
• amiloride hcl (RX) [Accessed 5 Jun. 2024] (online) Available at:
• Amiloride (MedlinePlus) [Accessed 2 Jun. 2024] (online) Available at:
• Sun Q, Sever P. Amiloride: A review. J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320975893. doi: 10.1177/1470320320975893. [Accessed 27 Jun. 2024] Available at: