Furmecil Capsule

Introduction

Furmecil is a prescription medication that contains three active ingredients: Gimeracil, Oteracil, and Tegafur. It is commonly prescribed under the brand name Furmecil. This medication is primarily used in the treatment of certain types of cancer, including gastric (stomach) cancer and colorectal cancer.

Uses

Furmecil is indicated for the treatment of advanced or metastatic gastric (stomach) cancer and colorectal cancer. It is typically used in combination with other medications and therapies as part of a comprehensive cancer treatment plan. Your healthcare provider will determine if Furmecil is appropriate for your specific condition.

Dosage and Administration

The dosage of Furmecil may vary depending on your individual circumstances and the specific cancer being treated. Follow your healthcare provider’s instructions regarding the dosage and duration of treatment.

Furmecil is usually taken orally, with or without food. Swallow the capsule whole with a glass of water. Do not crush, chew, or open the capsule, as this may alter the way the medication is released in your body.

If you miss a dose of Furmecil, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Mechanism of Action

Furmecil contains three active ingredients: Gimeracil, Oteracil, and Tegafur. These substances work together to inhibit the growth of cancer cells.

Tegafur is a prodrug, which means it is converted into an active form (5-fluorouracil) within the body. 5-fluorouracil interferes with the synthesis of DNA and RNA, ultimately leading to the inhibition of cancer cell growth.

Gimeracil helps to enhance the concentration of active 5-fluorouracil in tumor tissues by inhibiting its breakdown in the body.

Oteracil is included in the formulation to reduce the gastrointestinal toxicity associated with the use of Tegafur.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, loss of appetite, fatigue, and changes in taste sensation. These side effects are generally mild and should be reported to your healthcare provider if they persist or become bothersome.

Serious side effects of Furmecil may include severe allergic reactions, difficulty breathing, chest pain, unusual bleeding or bruising, and signs of infection. If you experience any of these symptoms, seek immediate medical attention.

Drug Interactions

Furmecil may interact with other medications, including certain anticoagulants, anticonvulsants, and certain chemotherapy drugs. Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products, to avoid potential drug interactions.

Precautions

Before taking Furmecil, inform your healthcare provider if you have any underlying medical conditions or if you are allergic to any medications. Disclose your complete medical history to ensure the safe and effective use of this medication.

Furmecil is contraindicated in individuals with a known hypersensitivity to any of its components. It should not be used during pregnancy or breastfeeding, as it may cause harm to the developing fetus or nursing infant.

Storage

Store Furmecil at room temperature, away from direct sunlight and moisture. Keep it out of the reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Furmecil exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop the medication without consulting your doctor.
• If you experience any new or worsening symptoms while taking Furmecil, such as persistent nausea or unexplained bleeding, inform your healthcare provider promptly.
• attend all scheduled appointments with your healthcare provider to monitor your response to the medication and to address any concerns or questions you may have.
• Maintain a healthy lifestyle by eating a balanced diet, staying physically active, and getting regular rest. These lifestyle factors can support your overall well-being during cancer treatment.
• If you have any questions or concerns about Furmecil or its potential side effects, do not hesitate to reach out to your healthcare provider or pharmacist for further information and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Lentinan Uses, Benefits & Dosage Herbal Database (Drugs.com) [Accessed 24 Jun. 2024] (online) Available at:
• Sumi T, Nakata H, Mori Y, Takahashi H. Tegafur/gimeracil/oteracil-induced eosinophilic pneumonia. Respirol Case Rep. 2020 Mar 10;8(4):e00551. doi: 10.1002/rcr2.551. eCollection 2020 May. [Accessed 21 Jun. 2024] Available at:
• Labianca R, Beretta GD, Mosconi S, Milesi L. The role of uracil-tegafur (UFT) in elderly patients with colorectal cancer. Crit Rev Oncol Hematol. 2004 Oct;52(1):73-80. doi: 10.1016/j.critrevonc.2004.06.001. [Accessed 18 Jun. 2024] Available at:
• Zhang X, Tian X, Wei Y, Deng H, Ma L, Chen Z. Activity and Safety of Tegafur, Gimeracil, and Oteracil Potassium for Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis. J Oncol. 2021 Mar 23;2021:6690275. doi: 10.1155/2021/6690275. eCollection 2021. [Accessed 23 Jun. 2024] Available at: