Glycine Irrigation 1.5% Infusion

Introduction

Glycine Irrigation is a prescription medication that contains the active ingredient Glycine. It is available in the form of an infusion and is used for the treatment of certain medical conditions.

Uses

Glycine Irrigation is commonly prescribed for the following conditions:

• Hepatic encephalopathy: It is used to manage hepatic encephalopathy, a condition characterized by impaired brain function due to liver disease.
• Surgical procedures: Glycine Irrigation may also be used during surgical procedures to induce muscle relaxation.

Dosage and Administration

The dosage of Glycine Irrigation will be determined by your healthcare provider based on your specific condition and response to treatment. It is administered intravenously (IV) under the supervision of a healthcare professional. The infusion is typically given slowly over a specified period of time.

Follow your healthcare provider’s instructions regarding the dosage and administration of this medication. Do not adjust the dosage or stop the infusion without consulting your healthcare provider.

Mechanism of Action

Glycine Irrigation contains Glycine, which works by acting as an inhibitory neurotransmitter in the central nervous system. It helps reduce the levels of toxic substances in the body that may contribute to hepatic encephalopathy. Additionally, Glycine acts as a skeletal muscle relaxant, aiding in surgical procedures.

Side Effects

Common side effects may include:

• Nausea
• Vomiting
• Headache
• Dizziness
• Drowsiness

Serious side effects are rare but can occur. If you experience any of the following side effects, seek immediate medical attention:

• Allergic reactions: such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Severe confusion
• Signs of liver problems: such as yellowing of the skin or eyes, dark urine, or persistent nausea/vomiting.
• Severe muscle weakness

If you experience any other unusual or persistent side effects, contact your healthcare provider.

Drug Interactions

Before starting Glycine Irrigation, inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Certain medications may interact with Glycine Irrigation, potentially affecting its effectiveness or increasing the risk of side effects.

Inform your healthcare provider if you are taking any of the following medications:

• Neuromuscular blocking agents: such as vecuronium or rocuronium.
• Medications that affect liver function: such as rifampin or phenytoin.

Disclose your complete medication history to ensure safe and effective use of Glycine Irrigation.

Precautions

Before using Glycine Irrigation, inform your healthcare provider of any allergies you have, especially if you are allergic to Glycine or any other ingredients in the medication. Discuss your medical history, including liver problems, with your healthcare provider to determine if Glycine Irrigation is suitable for you.

Certain precautions should be taken when using Glycine Irrigation:

• Pregnancy and breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Glycine Irrigation during pregnancy or breastfeeding should be discussed with your healthcare provider.
• Liver function: Glycine Irrigation may affect liver function. Regular monitoring of liver function may be required during treatment.
• Driving and operating machinery: Glycine Irrigation may cause drowsiness and dizziness. Avoid driving or operating machinery until you know how this medication affects you.

Storage

Glycine Irrigation should be stored in a cool, dry place, away from direct sunlight and moisture. Follow the storage instructions provided on the packaging or as directed by your healthcare provider. Keep this medication out of the reach of children.

Patient Tips

Here are some additional tips to keep in mind while using Glycine Irrigation:

• Follow the recommended dosage and administration instructions provided by your healthcare provider.
• If you miss a dose, contact your healthcare provider for further guidance.
• Be aware of the potential side effects of Glycine Irrigation and contact your healthcare provider if you experience any unusual or persistent symptoms.
• Inform your healthcare provider about any other medications you are taking, including over-the-counter, prescription, and herbal products.
• If you have any concerns or questions about Glycine Irrigation, do not hesitate to reach out to your healthcare provider for clarification.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Aminoplasmal 10% Solution for Infusion (Health Professionals SmPC) Available at:
• Glycine Prescribing Information (Drugs.com) [Accessed 27 Jun. 2024] (online) Available at:
• immune glob g (igg)-glycine solution (RX) [Accessed 17 Jun. 2024] (online) Available at:
• GLDC gene (MedlinePlus) [Accessed 9 Jun. 2024] (online) Available at:
• Hall JC. Glycine. JPEN J Parenter Enteral Nutr. 1998 Nov-Dec;22(6):393-8. doi: 10.1177/0148607198022006393. [Accessed 21 Jun. 2024] Available at: