Histaglobulin Injection

Introduction

Histaglobulin is a prescription medication that combines three active ingredients: Human Normal Immunoglobulin, Histamine Dihydrochloride, and Sodium Thiosulphate. It is used for the treatment of certain conditions and diseases.

Uses

Histaglobulin is prescribed for the following conditions:

• Immunodeficiency disorders: It is used to boost the immune system and prevent infections in individuals with immunodeficiency disorders.
• Allergic reactions: It can be used to alleviate symptoms of allergic reactions, such as itching, redness, and swelling.
• Poisoning: Histaglobulin may be administered in cases of certain poisonings to help neutralize toxins.

Dosage and Administration

Histaglobulin should be administered under the supervision of a healthcare professional. The dosage and administration method may vary depending on the specific condition being treated. It is usually given as an intravenous injection. The healthcare provider will determine the appropriate dosage and frequency of administration for each individual.

Mechanism of Action

Histaglobulin works through the combined actions of its active ingredients:

• Human Normal Immunoglobulin: It provides passive immunity by supplying antibodies to help fight infections.
• Histamine Dihydrochloride: It helps to relieve allergic symptoms by blocking the effects of histamine, a chemical released during allergic reactions.
• Sodium Thiosulphate: It acts as an antidote for certain types of poisoning by helping to neutralize toxins.

Side Effects

Common side effects of Histaglobulin may include:

• Injection site reactions, such as pain or redness
• Headache
• Nausea or vomiting
• Fever or chills

Serious side effects are rare, but if any of the following occur, seek immediate medical attention:

• Severe allergic reactions, such as difficulty breathing or swelling of the face, lips, tongue, or throat
• Chest pain or tightness
• Rapid heart rate
• Seizures

Drug Interactions

Histaglobulin may interact with certain medications. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products. Some examples of potential drug interactions include:

• Medications that suppress the immune system, such as corticosteroids or immunosuppressants
• Antihistamines or other medications that may cause drowsiness
• Medications that affect blood clotting, such as anticoagulants

follow your healthcare provider’s instructions and inform them of all the medications you are taking to avoid any potential interactions.

Precautions

Before using Histaglobulin, consider the following precautions:

• Allergies: Inform your healthcare provider if you are allergic to any of the active ingredients in Histaglobulin or if you have had a previous allergic reaction to immunoglobulin products.
• Medical conditions: Discuss any underlying medical conditions with your healthcare provider, especially if you have a history of heart disease, blood clotting disorders, or kidney problems.
• Pregnancy and breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the use of Histaglobulin during pregnancy or breastfeeding should be weighed against potential risks.

Storage

Histaglobulin should be stored according to the instructions provided by the manufacturer. It is typically recommended to store it in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). Do not freeze the medication. Keep it out of the reach of children and away from direct sunlight.

Patient Tips

Here are some additional tips for patients using Histaglobulin:

• Follow the dosage and administration instructions provided by your healthcare provider.
• If you experience any side effects or have concerns, contact your healthcare provider promptly.
• Keep track of the expiration date of the medication and dispose of any expired or unused medication properly.
• Inform your healthcare provider about any other medications or supplements you are taking before starting Histaglobulin.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Common questions about sodium cromoglicate eye drops (NHS UK) [Accessed 2 Jun. 2024] (online) Available at:
• Haemoctin (Health Professionals SmPC) Available at:
• Histamine Phosphate Prescribing Information (Drugs.com) [Accessed 28 Jun. 2024] (online) Available at:
• cinqair 10 mg/ml intravenous solution monoclonal antibody, human interleukin 5 antagonist (RX) [Accessed 28 Jun. 2024] (online) Available at:
• Cluster headache (MedlinePlus) [Accessed 20 Jun. 2024] (online) Available at:
• Yang LP, Perry CM. Histamine dihydrochloride: in the management of acute myeloid leukaemia. Drugs. 2011 Jan 1;71(1):109-22. doi: 10.2165/11206410-000000000-00000. [Accessed 11 Jun. 2024] Available at: