Kallistat Injection

Introduction

Kallistat is a prescription medication that contains the active ingredient Aprotinin. It is available under the brand name Kallistat. This medication is primarily used in the management of bleeding during surgeries, particularly in patients undergoing open-heart surgery.

Uses

Kallistat is prescribed to control bleeding during surgical procedures, especially those involving cardiac surgeries. It helps to reduce blood loss and maintain hemostasis, which is crucial for successful surgical outcomes.

Dosage and Administration

The dosage of Kallistat will be determined by your healthcare provider based on various factors such as the type of surgery, your body weight, and your medical condition. It is typically administered by a healthcare professional as an intravenous infusion during surgery.

Mechanism of Action

Aprotinin, the active ingredient in Kallistat, works by inhibiting certain enzymes in the body that break down blood clots. By doing so, it helps to prevent excessive bleeding during surgery and promotes the formation of stable blood clots, aiding in the control of surgical bleeding.

Side Effects

Common side effects may include nausea, vomiting, fever, and mild allergic reactions such as skin rashes. Serious side effects are rare but can include severe allergic reactions, kidney problems, and cardiovascular complications. If you experience any severe or persistent side effects, seek medical attention immediately.

Drug Interactions

Kallistat may interact with certain medications, including anticoagulants (blood thinners) and antiplatelet drugs. Inform your healthcare provider about all the medications you are currently taking to avoid any potential drug interactions.

Precautions

Before using Kallistat, inform your healthcare provider about any known allergies, especially to aprotinin or any other ingredients in the medication. Additionally, certain medical conditions such as kidney disease or a history of heart problems may require special caution and monitoring while using this medication. Follow your healthcare provider’s instructions and inform them about your medical history and any medications you are taking.

Storage

Kallistat should be stored in a cool and dry place, away from direct sunlight and out of the reach of children. It should be stored at the recommended temperature as mentioned on the packaging or as advised by your healthcare provider.

Patient Tips

• Follow the dosage and administration instructions provided by your healthcare provider strictly.
• Report any unusual or bothersome side effects to your healthcare provider promptly.
• Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements.
• Keep a record of any allergic reactions you may have experienced in the past and inform your healthcare provider about them.
• Store the medication properly, following the recommended storage instructions.
• If you have any concerns or questions regarding the use of Kallistat, do not hesitate to reach out to your healthcare provider for clarification and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Aprotinin 10,000 KIU/ml Injection BP (Health Professionals SmPC) Available at:
• Aprotinin (Drugs.com) [Accessed 10 Jun. 2024] (online) Available at:
• Index to Drug-Specific Information (Food and Drug Administration) [Accessed 13 Jun. 2024] (online) Available at:
• Ivachtchenko AV, Ivashchenko AA, Shkil DO, Ivashchenko IA. Aprotinin-Drug against Respiratory Diseases. Int J Mol Sci. 2023 Jul 6;24(13):11173. doi: 10.3390/ijms241311173. [Accessed 18 Jun. 2024] Available at: