Koflar Syrup

Introduction

Koflar is a prescription medication that contains two active ingredients: Methylcobalamin and Pregabalin. It is available in syrup form and is commonly used to treat certain neurological conditions.

Uses

Koflar is primarily prescribed for the management of neuropathic pain, which is a type of pain caused by damage or dysfunction of the nerves. It is also used in the treatment of peripheral neuropathy, a condition characterized by numbness, tingling, and pain in the hands and feet. Additionally, this medication may be prescribed for certain vitamin B12 deficiencies.

Dosage and Administration

The dosage of Koflar may vary depending on the specific condition being treated and the individual patient. Follow the instructions provided by your healthcare professional. Generally, the recommended dose for adults is 10 ml (equivalent to 2 teaspoons) taken orally, twice daily. The syrup should be measured using the provided dosing cup or spoon.

Mechanism of Action

Methylcobalamin, one of the active ingredients in Koflar, is a form of vitamin B12. It plays a crucial role in the synthesis of myelin, a protective covering around nerve fibers. By providing the body with an adequate amount of methylcobalamin, this medication helps support nerve function and may alleviate certain neuropathic symptoms.

Pregabalin, the other active ingredient, is a medication that belongs to a class of drugs known as anticonvulsants. It works by binding to certain calcium channels in the central nervous system, which reduces the release of certain neurotransmitters involved in pain signaling. This action helps to decrease the intensity of neuropathic pain.

Side Effects

Common side effects may include dizziness, drowsiness, headache, and gastrointestinal disturbances such as nausea or diarrhea. These side effects are generally mild and temporary.

In rare cases, more serious side effects may occur. These can include severe allergic reactions, such as rash, itching, or swelling; difficulty breathing; or changes in mood or behavior. If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Koflar may interact with certain medications, including other anticonvulsants, alcohol, and central nervous system depressants. Inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to ensure there are no potential interactions.

Precautions

Before starting Koflar, inform your healthcare professional about any allergies you may have, as well as any medical conditions you have or medications you are taking. This medication should be used with caution in individuals with a history of kidney problems or those who are pregnant or breastfeeding.

Koflar should not be used by individuals who are allergic to Methylcobalamin, Pregabalin, or any of the other ingredients in the syrup. It is also contraindicated in individuals with known hypersensitivity to cobalt or vitamin B12.

Storage

Koflar should be stored in a cool, dry place away from direct sunlight. It should be kept out of reach of children and pets. Do not use the syrup beyond the expiration date printed on the packaging. If you have any expired or unused medication, please consult with your pharmacist on the appropriate disposal methods.

Patient Tips

• Take Koflar exactly as prescribed by your healthcare professional. Do not exceed the recommended dose.
• If you forget to take a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Avoid consuming alcohol while taking Koflar, as it may increase the risk of drowsiness and dizziness.
• If you experience any new or worsening symptoms while taking this medication, inform your healthcare professional promptly.
• Keep regular follow-up appointments with your healthcare professional to monitor your progress and discuss any concerns or questions you may have.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Pregabalin: medicine to treat epilepsy and anxiety (NHS UK) [Accessed 18 Jun. 2024] (online) Available at:
• Alzain 100 mg Capsules, Hard (Health Professionals SmPC) Available at:
• Methylcobalamin vitamin B12 (Drugs.com) [Accessed 25 Jun. 2024] (online) Available at:
• pregabalin (lyrica) (RX) [Accessed 18 Jun. 2024] (online) Available at:
• ABCD4 gene (MedlinePlus) [Accessed 5 Jun. 2024] (online) Available at:
• Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. doi: 10.1155/2013/424651. Epub 2013 Dec 26. [Accessed 26 Jun. 2024] Available at: