Kylonib 200mg Tablet

Introduction

Kylonib is a prescription medication that contains the active ingredient Nilotinib. It is available under the brand name Kylonib. This medication is primarily used in the treatment of certain types of leukemia, specifically chronic myeloid leukemia (CML).

Uses

Kylonib is prescribed to patients diagnosed with chronic myeloid leukemia (CML). It is utilized in the treatment of CML that is resistant to other therapies or in cases where other treatments have not been effective. It works by inhibiting the growth of cancer cells and reducing the progression of the disease.

Dosage and Administration

Kylonib should be taken exactly as prescribed by your healthcare provider. The dosage and duration of treatment may vary based on individual factors such as the stage of the disease and your overall health. Follow your doctor’s instructions carefully.

Typically, the recommended dose for adult patients is 300 mg of Kylonib taken orally twice daily, with food. The tablets should be swallowed whole with a glass of water and should not be crushed, chewed, or broken.

Mechanism of Action

Kylonib belongs to a class of medications known as tyrosine kinase inhibitors. It works by inhibiting the activity of a protein called BCR-ABL, which is responsible for the abnormal growth and division of cancer cells. By blocking this protein, Kylonib helps to slow down the progression of chronic myeloid leukemia.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, fatigue, headache, and muscle pain. These side effects are usually mild and temporary, but if they persist or worsen. Inform your healthcare provider.

Serious side effects are rare but can occur. These may include heart problems, liver problems, pancreatitis, and bleeding disorders. If you experience any severe or concerning side effects, seek immediate medical attention.

Drug Interactions

Kylonib may interact with other medications, including over-the-counter drugs, herbal supplements, and vitamins. Inform your healthcare provider about all the medications you are taking to avoid any potential interactions. Some common drugs that may interact with Kylonib include certain antibiotics, antifungal medications, and antacids.

Precautions

Before starting Kylonib, discuss your medical history and any current medications with your healthcare provider. Inform them if you have any history of heart problems, liver disease, or pancreatitis. Additionally, certain medications may interact with Kylonib, so disclose all medications you are taking.

Kylonib may cause QT prolongation, a heart rhythm disorder. Inform your doctor if you have any heart conditions or a family history of heart problems. Regular monitoring of heart function may be required during treatment.

Storage

Kylonib should be stored at room temperature, away from moisture and heat. Keep the tablets in their original container, and make sure to close the lid tightly after each use. Do not store this medication in the bathroom or kitchen where it can be exposed to moisture.

Patient Tips

• take Kylonib exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor.
• Take the tablets with food to help minimize stomach upset.
• If you miss a dose, take it as soon as you remember, unless it is close to the time for your next scheduled dose. Do not double the dose to make up for a missed one.
• If you experience any severe or persistent side effects, contact your healthcare provider immediately.
• Regular follow-up appointments with your doctor are important to monitor your response to treatment and to check for any potential adverse effects.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Mastocytosis – Treatment (NHS UK) [Accessed 1 Jun. 2024] (online) Available at:
• Tasigna 150mg Hard Capsules (Health Professionals SmPC) Available at:
• Nilotinib (Drugs.com) [Accessed 19 Jun. 2024] (online) Available at:
• nilotinib capsule (RX) [Accessed 29 Jun. 2024] (online) Available at:
• Nilotinib (MedlinePlus) [Accessed 8 Jun. 2024] (online) Available at:
• Kantarjian HM, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Boquimpani C, Pasquini R, Clark RE, Dubruille V, Flinn IW, Kyrcz-Krzemien S, Medras E, Zanichelli M, Bendit I, Cacciatore S, Titorenko K, Aimone P, Saglio G, Hochhaus A. Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis. Leukemia. 2021 Feb;35(2):440-453. doi: 10.1038/s41375-020-01111-2. Epub 2021 Jan 7. [Accessed 16 Jun. 2024] Available at: