Largyl O Tablet

Introduction

Largyl O is a prescription medication that contains two active ingredients: Ofloxacin and Metronidazole. It is available under the brand name Largyl O. This medication is primarily used to treat bacterial and protozoal infections.

Uses

Largyl O is commonly prescribed for the following conditions:

• Bacterial infections: It is effective in treating various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and sexually transmitted infections.
• Protozoal infections: Largyl O is also used in the treatment of certain protozoal infections, such as amoebiasis and giardiasis.

Dosage and Administration

The dosage of Largyl O may vary depending on the specific condition being treated and the individual patient’s response. Follow the instructions provided by your healthcare professional. Generally, the recommended dosage for adults is:

• For bacterial infections: Take one tablet twice daily, with or without food, for a duration prescribed by your doctor. The treatment duration may range from a few days to a few weeks, depending on the severity of the infection.
• For protozoal infections: Take one tablet three times daily, with or without food, for a duration determined by your doctor. The treatment duration may vary depending on the type and location of the infection.

Complete the full course of treatment, even if you start feeling better before the prescribed duration is over.

Mechanism of Action

Largyl O contains two active ingredients that work in different ways to fight infections:

• Ofloxacin: It belongs to a class of antibiotics called fluoroquinolones. Ofloxacin works by inhibiting the enzymes that bacteria need to replicate and survive. This helps to kill the bacteria or prevent their growth, leading to the resolution of the infection.
• Metronidazole: It is an antiprotozoal and antibacterial agent. Metronidazole works by interfering with the DNA synthesis of the bacteria and protozoa, leading to their destruction.

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Headache
• Dizziness
• Abdominal pain
• Skin rash

If any of these side effects persist or worsen, consult your healthcare professional.

In rare cases, Largyl O may cause serious side effects. Contact your doctor immediately if you experience any of the following:

• Allergic reactions, such as rash, itching, swelling, or difficulty breathing
• Severe diarrhea or abdominal pain
• Changes in vision or eye pain
• Signs of liver problems, such as yellowing of the skin or eyes, dark urine, or persistent nausea

Drug Interactions

Largyl O may interact with other medications, which can affect its effectiveness or increase the risk of side effects. Some common and serious drug interactions include:

• Warfarin: Largyl O may increase the effects of warfarin, a blood-thinning medication, leading to an increased risk of bleeding. Inform your doctor if you are taking warfarin or any other blood-thinning medications.
• Antacids: Taking antacids that contain aluminum or magnesium hydroxide may reduce the absorption of Largyl O. It is recommended to take the antacids at least 2 hours before or after taking Largyl O.
• Other medications: Inform your healthcare professional about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions.

Precautions

Before taking Largyl O, consider the following precautions:

• Allergies: Inform your doctor if you have a known allergy to Ofloxacin, Metronidazole, or any other fluoroquinolones, nitroimidazoles, or related medications.
• Pregnancy and breastfeeding: Largyl O should be used with caution during pregnancy and breastfeeding. Discuss the risks and benefits with your healthcare professional before starting the medication.
• Pre-existing medical conditions: Inform your doctor if you have any pre-existing medical conditions, such as kidney or liver disease, blood disorders, or neurological disorders, as these may affect the suitability of Largyl O.

Storage

Largyl O should be stored at room temperature, away from direct sunlight and moisture. Keep it out of the reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

Here are some additional tips for patients using Largyl O:

• Take the medication exactly as prescribed by your healthcare professional. Do not take more or less than the recommended dose.
• If you experience any severe or persistent side effects, contact your doctor immediately.
• Finish the full course of treatment, even if you start feeling better before the prescribed duration is over.
• Do not share your medication with others, as it is prescribed specifically for your condition.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• follow good hygiene practices, such as washing your hands regularly, to prevent the spread of infections.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Metronidazole: antibiotic to treat infections (NHS UK) [Accessed 6 Jun. 2024] (online) Available at:
• Acea 0.75% w/w Gel (Health Professionals SmPC) Available at:
• Metronidazole (Drugs.com) [Accessed 26 Jun. 2024] (online) Available at:
• metronidazole (RX) [Accessed 5 Jun. 2024] (online) Available at:
• Metronidazole Injection (MedlinePlus) [Accessed 5 Jun. 2024] (online) Available at:
• Dingsdag SA, Hunter N. Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms. J Antimicrob Chemother. 2018 Feb 1;73(2):265-279. doi: 10.1093/jac/dkx351. [Accessed 12 Jun. 2024] Available at: