Lenvatinib 4mg Tablet

Introduction

Lenvatinib is a prescription medication that contains the active ingredient Lenvatinib. It is available under the brand name Lenvatinib. This medication is commonly used in the treatment of certain types of cancer.

Uses

Lenvatinib is primarily prescribed for the treatment of the following conditions:

• Differentiated thyroid cancer: It is used to treat locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
• Renal cell carcinoma: It is used in combination with everolimus to treat advanced renal cell carcinoma after one prior anti-angiogenic therapy.
• Hepatocellular carcinoma: It is used to treat locally advanced or metastatic hepatocellular carcinoma who have received no prior systemic therapy.

Note that Lenvatinib should only be taken under the supervision of a healthcare professional.

Dosage and Administration

The dosage of Lenvatinib may vary depending on the specific condition being treated and individual patient factors. Follow the dosage instructions provided by your healthcare provider.

Generally, Lenvatinib is taken orally, with or without food. The tablets should be swallowed whole with a glass of water. Do not crush, chew, or break the tablets unless instructed by your healthcare provider.

Adhere to the prescribed dosage and schedule. Do not increase or decrease the dose without consulting your doctor.

Mechanism of Action

Lenvatinib contains Lenvatinib, which belongs to a class of medications called kinase inhibitors. It works by blocking the action of certain proteins that are involved in the growth and spread of cancer cells. By inhibiting these proteins, Lenvatinib helps to slow down or stop the growth of cancer cells.

Side Effects

Common side effects may include:

• High blood pressure
• Diarrhea
• Fatigue
• Decreased appetite
• Nausea
• Weight loss
• Proteinuria (excess protein in the urine)

note that not all patients will experience these side effects, and the severity may vary. If you experience any persistent or bothersome side effects. Inform your healthcare provider.

In some cases, Lenvatinib may cause more serious side effects. These can include:

• Severe bleeding
• Hypertension (high blood pressure)
• Impaired wound healing
• Arterial thromboembolic events (blood clots in arteries)
• Proteinuria (excess protein in the urine)

If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Lenvatinib may interact with other medications and substances. Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Some common drug interactions with Lenvatinib include:

• Strong CYP3A4 inhibitors: These medications can increase the concentration of Lenvatinib in the body, leading to an increased risk of side effects.
• Strong CYP3A4 inducers: These medications can decrease the concentration of Lenvatinib in the body, potentially reducing its effectiveness.

Discuss all potential drug interactions with your healthcare provider to ensure the safe and effective use of Lenvatinib.

Precautions

Before taking Lenvatinib. Discuss any pre-existing medical conditions or allergies with your healthcare provider. Inform your doctor if you have a history of:

• High blood pressure
• Bleeding problems
• Heart problems
• Liver or kidney problems
• Thyroid problems

Lenvatinib may not be suitable for everyone, and your healthcare provider will assess whether it is appropriate for you.

Additionally, Lenvatinib may interact with other medications or substances, including herbal products and dietary supplements. Disclose all medications and substances you are taking to your healthcare provider.

Storage

Lenvatinib should be stored at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children. Do not use Lenvatinib if it has expired or if the packaging appears to be damaged.

Patient Tips

Here are some tips to help you safely and effectively use Lenvatinib:

• Take Lenvatinib exactly as prescribed by your healthcare provider.
• Do not modify the dosage or stop taking the medication without consulting your doctor.
• If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• If you experience any bothersome or persistent side effects, inform your healthcare provider.
• Attend all scheduled appointments with your healthcare provider for monitoring and follow-up.
• Store Lenvatinib in a cool, dry place, away from direct sunlight and moisture.
• Dispose of any unused or expired medication properly, following local regulations or guidelines.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Kisplyx 10 mg hard capsules (Health Professionals SmPC) Available at:
• Lenvatinib (Drugs.com) [Accessed 4 Jun. 2024] (online) Available at:
• lenvatinib capsule (RX) [Accessed 9 Jun. 2024] (online) Available at:
• Lenvatinib (MedlinePlus) [Accessed 22 Jun. 2024] (online) Available at:
• Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. [Accessed 2 Jun. 2024] Available at: