Lexof O Plus Oral Suspension

Introduction

Lexof O Plus is a medication that combines two active ingredients: Racecadotril and Ofloxacin. It is available in the form of an oral suspension and is commonly prescribed by healthcare professionals.

Uses

Lexof O Plus is primarily used to treat gastrointestinal infections caused by certain bacteria. It is effective in reducing the symptoms associated with these infections, such as diarrhea, abdominal pain, and discomfort.

Dosage and Administration

The dosage of Lexof O Plus may vary depending on the severity of the infection and the patient’s age and weight. Follow the instructions provided by your healthcare professional or the information on the product label.

Typically, the recommended dosage for adults and children above 12 years of age is 10 ml of the suspension taken twice daily for a course of 5-7 days. For children between 2-12 years of age, the dosage is usually based on body weight and may vary. Consult with your healthcare professional for the appropriate dosage for your child.

The suspension should be shaken well before each use. It is generally taken with or without food, but it is advisable to follow any specific instructions provided by your healthcare professional.

Mechanism of Action

Racecadotril, one of the active ingredients in Lexof O Plus, works by inhibiting the activity of an enzyme called enkephalinase. This enzyme is responsible for breaking down substances in the intestine that regulate the secretion of fluids and electrolytes. By inhibiting enkephalinase, Racecadotril helps to reduce excessive fluid secretion in the intestine, leading to a decrease in diarrhea.

Ofloxacin, the other active ingredient, belongs to a class of antibiotics called fluoroquinolones. It works by interfering with the DNA replication process in bacteria, thereby inhibiting their growth and preventing the spread of infection.

Side Effects

Lexof O Plus, like any medication, may cause side effects in some individuals. Common side effects may include nausea, vomiting, stomach upset, and mild allergic reactions such as rash or itching. These side effects are usually mild and resolve on their own without any intervention.

However, if you experience any serious side effects such as severe abdominal pain, persistent diarrhea, dizziness, or difficulty breathing, seek immediate medical attention.

Drug Interactions

Lexof O Plus may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Some common drug interactions include:

• Antacids: These may decrease the absorption of Ofloxacin, so it is recommended to take Lexof O Plus at least 2 hours before or 2 hours after taking antacids.
• Warfarin: The combination of Ofloxacin and Warfarin may increase the risk of bleeding. Regular monitoring of blood clotting time is advisable if these medications are used together.
• Nonsteroidal anti-inflammatory drugs (NSAIDs): Ofloxacin may increase the risk of seizures when used with certain NSAIDs. Caution should be exercised when using these medications together.

Consult with your healthcare professional for a comprehensive list of potential drug interactions.

Precautions

Before using Lexof O Plus, inform your healthcare professional about any allergies you may have, especially to fluoroquinolone antibiotics or any other medications.

Certain precautions should be taken into consideration:

• Pregnancy and breastfeeding: The safety of Lexof O Plus during pregnancy and breastfeeding has not been established. Consult with your healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding.
• Renal impairment: Lexof O Plus should be used with caution in individuals with impaired kidney function, as dosage adjustments may be necessary.
• Central nervous system (CNS) disorders: Ofloxacin may cause CNS-related side effects such as dizziness, lightheadedness, or confusion. If you experience any of these symptoms, avoid activities that require mental alertness until you know how the medication affects you.

Storage

Lexof O Plus should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of the reach of children and pets. Do not use the suspension if it has expired or if the color or consistency has changed.

Patient Tips

Here are some additional tips to help you make the most of your treatment with Lexof O Plus:

• Take the medication exactly as prescribed by your healthcare professional. Do not exceed the recommended dosage or duration of treatment.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Complete the full course of treatment, even if your symptoms improve before the prescribed duration. This will help ensure the infection is completely cleared.
• If you experience any new or worsening symptoms during treatment, inform your healthcare professional promptly.
• Maintain good hygiene practices, such as regular handwashing, to prevent the spread of infection to others.
• If you have any questions or concerns about your treatment, do not hesitate to consult with your healthcare professional. They are best equipped to provide you with personalized advice and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• EXOCIN® 3 mg/ml Eye Drops, Solution. (Health Professionals SmPC) Available at:
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• ofloxacin (RX) [Accessed 17 Jun. 2024] (online) Available at:
• Ofloxacin (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Hsiao SH, Chang CM, Tsao CJ, Lee YY, Hsu MY, Wu TJ. Acute rhabdomyolysis associated with ofloxacin/levofloxacin therapy. Ann Pharmacother. 2005 Jan;39(1):146-9. doi: 10.1345/aph.1E285. Epub 2004 Nov 23. [Accessed 13 Jun. 2024] Available at: