Lupex-Plus Tablet

Introduction

Lupex-Pluss are a prescription medication that contains two active ingredients: duloxetine and methylcobalamin. Duloxetine is an antidepressant medication belonging to the class of drugs known as selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Methylcobalamin is a form of vitamin B12 that helps support nerve health. Lupex-Pluss are primarily used to treat depressive disorders and neuropathic pain associated with certain conditions.

Uses

Lupex-Pluss are prescribed for the treatment of:

• Major depressive disorder: Lupex-Plus can help improve mood and alleviate symptoms of depression.
• Diabetic neuropathy: Lupex-Plus can help relieve neuropathic pain associated with diabetes.
• Postherpetic neuralgia: Lupex-Plus can provide relief from nerve pain that occurs after an episode of shingles.

Note that Lupex-Pluss should only be used under the guidance and supervision of a healthcare professional.

Dosage and Administration

• The recommended dosage of Lupex-Pluss may vary depending on the individual’s condition and response to treatment. Follow the instructions provided by your healthcare provider.
• Lupex-Pluss are usually taken orally, with or without food.
• Swallow the tablet whole, without crushing or chewing it, to ensure the proper release of the medication.
• It is recommended to take Lupex-Pluss at the same time each day to help establish a routine.

Mechanism of Action

Lupex-Pluss work by increasing the levels of certain chemicals in the brain, such as serotonin and norepinephrine. This helps to regulate mood and reduce the perception of pain. Duloxetine, the active ingredient in Lupex-Plus, inhibits the reuptake of these neurotransmitters, allowing them to remain in the synapses for a longer period of time and exert their effects.

Side Effects

Common side effects may include:

• Nausea
• Dry mouth
• Headache
• Dizziness
• Fatigue

In some cases, Lupex-Pluss may cause more serious side effects. If you experience any of the following, seek medical attention immediately:

• Suicidal thoughts or behavior
• Changes in mood or behavior
• Allergic reactions (rash, itching, swelling, difficulty breathing)
• Unusual bleeding or bruising
• Severe dizziness or fainting

Drug Interactions

inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Lupex-Pluss may interact with certain medications, including:

• Monoamine oxidase inhibitors (MAOIs)
• Other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs)
• Blood thinners (anticoagulants)

These are not the only possible drug interactions. Your healthcare provider will have a complete list of medications to avoid while taking Lupex-Pluss.

Precautions

Before starting Lupex-Pluss, discuss any medical conditions or allergies you have with your healthcare provider. They may need to adjust the dosage or monitor you more closely if you have a history of:

• Liver or kidney problems
• Seizures
• Bipolar disorder
• Glaucoma

Lupex-Pluss should not be used by individuals who are allergic to duloxetine or methylcobalamin. Avoid alcohol while taking Lupex-Plus, as it may increase the risk of side effects.

Storage

Patient Tips

• Take Lupex-Pluss as directed by your healthcare provider. Do not exceed the recommended dosage.
• It may take several weeks for the full effects of Lupex-Pluss to be felt. Continue taking the medication even if you start to feel better, unless instructed otherwise by your healthcare provider.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
• Avoid abrupt discontinuation of Lupex-Pluss, as this may lead to withdrawal symptoms. If you wish to stop taking the medication, consult your healthcare provider for guidance on tapering the dose gradually.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Duloxetine: medicine to treat depression and anxiety (NHS UK) [Accessed 23 Jun. 2024] (online) Available at:
• Cymbalta 30mg hard gastro-resistant capsules (Health Professionals SmPC) Available at:
• Duloxetine (Drugs.com) [Accessed 7 Jun. 2024] (online) Available at:
• duloxetine 60 mg capsule,delayed release sprinkle (RX) [Accessed 12 Jun. 2024] (online) Available at:
• Duloxetine (MedlinePlus) [Accessed 15 Jun. 2024] (online) Available at:
• Migliorini F, Maffulli N, Eschweiler J, Baroncini A, Bell A, Colarossi G. Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis. J Orthop Surg Res. 2023 Jul 17;18(1):504. doi: 10.1186/s13018-023-03995-z. [Accessed 8 Jun. 2024] Available at: