M-Fost 500mg Injection

Introduction

M-Fost is a medication that contains the active ingredient Amifostine. It is available in the form of an injection and is used for various medical purposes.

Uses

M-Fost is primarily prescribed as a cytoprotective agent. It is used to reduce the harmful effects of certain chemotherapy drugs on normal cells. This medication helps protect healthy tissues from the toxic effects of chemotherapy, particularly in patients receiving treatment for certain types of cancer, such as head and neck cancer.

Dosage and Administration

The dosage of M-Fost may vary depending on the specific treatment plan and individual patient factors. It is typically administered intravenously under the supervision of a healthcare professional. The injection is given before chemotherapy, and the dose and frequency of administration will be determined by your healthcare provider. Follow the instructions provided by your doctor or nurse regarding the correct administration of this medication.

Mechanism of Action

Amifostine, the active ingredient in M-Fost, is a prodrug that is converted into an active compound called WR-1065 in the body. WR-1065 acts as a free radical scavenger, meaning it helps neutralize harmful reactive oxygen species that are generated during chemotherapy. By reducing the oxidative stress on normal cells, M-Fost helps minimize the damage caused by chemotherapy drugs and protects healthy tissues.

Side Effects

Common side effects may include nausea, vomiting, low blood pressure, and allergic reactions. Report any unusual or severe side effects to your healthcare provider promptly. In rare cases, serious side effects such as allergic reactions (e.g., difficulty breathing, swelling of the face or throat) or severe skin reactions may occur. If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

M-Fost may interact with other medications. Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), may interact with M-Fost and increase the risk of side effects. Your healthcare provider will assess the potential interactions and adjust your treatment plan accordingly.

Precautions

Before using M-Fost, inform your healthcare provider about any medical conditions you have, especially if you have a history of kidney problems or low blood pressure. This medication may not be suitable for everyone, and your doctor will evaluate the potential risks and benefits before prescribing it to you. Additionally, avoid alcohol consumption while receiving M-Fost, as it may increase the risk of side effects.

Storage

M-Fost should be stored at the recommended temperature, typically between 20°C and 25°C (68°F and 77°F). It should be protected from light and kept out of the reach of children. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Follow the instructions provided by your healthcare provider regarding the timing and frequency of M-Fost administration.
• Inform your doctor or nurse if you experience any unusual or severe side effects.
• Keep a record of any side effects you experience and discuss them with your healthcare provider during your next visit.
• If you have any concerns or questions about M-Fost, do not hesitate to reach out to your healthcare provider for clarification.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Amifostine (Drugs.com) [Accessed 30 Jun. 2024] (online) Available at:
• amifostine crystalline 500 mg intravenous solution (RX) [Accessed 15 Jun. 2024] (online) Available at:
• Amifostine Injection (MedlinePlus) [Accessed 6 Jun. 2024] (online) Available at:
• Ji L, Cui P, Zhou S, Qiu L, Huang H, Wang C, Wang J. Advances of Amifostine in Radiation Protection: Administration and Delivery. Mol Pharm. 2023 Nov 6;20(11):5383-5395. doi: 10.1021/acs.molpharmaceut.3c00600. Epub 2023 Sep 25. [Accessed 6 Jun. 2024] Available at: