Malarce Tablet

Introduction

Malarce is a medication that contains the active ingredients Pyrimethamine and Sulfamethoxazole. It is commonly known by its generic name and is available under the brand name Malarce. This medication is primarily used for the treatment of certain types of infections.

Uses

Malarce is prescribed for the treatment of toxoplasmosis, a parasitic infection caused by Toxoplasma gondii. It is also used to prevent and treat a type of pneumonia (pneumocystis carinii pneumonia) in people with weakened immune systems, such as patients with HIV infection.

Dosage and Administration

The dosage of Malarce will be determined by your healthcare provider based on your medical condition and response to treatment. It is typically taken orally with a full glass of water. It’s important to follow the dosage instructions provided by your doctor or pharmacist.

Mechanism of Action

Pyrimethamine and Sulfamethoxazole work together to inhibit the growth of the microorganisms causing the infections. Pyrimethamine interferes with the production of folate, which is essential for the synthesis of DNA and RNA in the parasites, while Sulfamethoxazole prevents the bacteria from utilizing a substance called para-aminobenzoic acid, which is also needed for the production of DNA.

Side Effects

Common side effects of Malarce may include nausea, vomiting, diarrhea, and dizziness. Serious side effects could include allergic reactions, severe skin reactions, and blood disorders. If you experience any serious side effects, seek immediate medical attention.

Drug Interactions

Malarce may interact with certain medications such as warfarin, phenytoin, and methotrexate. It’s important to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.

Precautions

Before taking Malarce, inform your doctor about any allergies, especially to sulfa drugs. This medication may also interact with certain other drugs, so it’s crucial to disclose your complete medication history to your healthcare provider. Additionally, avoid exposure to sunlight and sunlamps while taking this medication, as it may increase the risk of sunburn.

Storage

Malarce should be stored at room temperature, away from light and moisture. Keep this medication out of the reach of children and pets.

Patient Tips

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Co-Trimoxazole 16 mg/ 80mg per ml for Infusion (Health Professionals SmPC) Available at:
• Pyrimethamine (Drugs.com) [Accessed 29 Jun. 2024] (online) Available at:
• pyrimethamine 25 mg tablet antimalarial drugs (RX) [Accessed 28 Jun. 2024] (online) Available at:
• Folic Acid (MedlinePlus) [Accessed 13 Jun. 2024] (online) Available at:
• Ramchandani S, Mohan CD, Mistry JR, Su Q, Naz I, Rangappa KS, Ahn KS. The multifaceted antineoplastic role of pyrimethamine against human malignancies. IUBMB Life. 2022 Mar;74(3):198-212. doi: 10.1002/iub.2590. Epub 2022 Jan 5. [Accessed 23 Jun. 2024] Available at: