Meroev-TZ 1.125gm Injection

Introduction

Meroev-TZ is a prescription medication that contains two active ingredients: Meropenem and Tazobactam. It is commonly used in the treatment of bacterial infections. Meropenem is a broad-spectrum antibiotic, while Tazobactam is a beta-lactamase inhibitor. Together, these two ingredients work synergistically to combat a wide range of bacterial infections.

Uses

Meroev-TZ is indicated for the treatment of various infections caused by susceptible bacteria. It is commonly prescribed for conditions such as:

• Intra-abdominal infections
• Skin and soft tissue infections
• Urinary tract infections
• Gynecological infections
• Lower respiratory tract infections
• Bacterial meningiti.

Note that Meroev-TZ should only be used for bacterial infections and is not effective against viral infections such as the common cold or flu.

Dosage and Administration

Meroev-TZ should be administered under the supervision of a healthcare professional. The dosage and duration of treatment will depend on the specific infection being treated, the patient’s age, and their overall health condition. It is typically given intravenously (IV) over a period of 30 minutes to 2 hours.

The healthcare provider will determine the appropriate dosage for each individual based on factors such as the severity of the infection and the patient’s kidney function. Follow the prescribed dosage and complete the full course of treatment, even if symptoms improve before the medication is finished.

Mechanism of Action

Meropenem, one of the active ingredients in Meroev-TZ, is a carbapenem antibiotic that works by inhibiting the growth of bacteria. It does this by interfering with the synthesis of bacterial cell walls, leading to the eventual death of the bacteria.

Tazobactam, the other active ingredient, is a beta-lactamase inhibitor. It works by blocking the action of beta-lactamase enzymes produced by certain bacteria. This helps to protect Meropenem from being broken down by the bacteria, allowing it to remain effective against a broader range of bacteria.

Side Effects

Common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Rash
• Local pain or irritation at the injection site

contact your healthcare provider if any of these side effects persist or worsen.

In rare cases, Meroev-TZ may cause more serious side effects. These can include:

• Allergic reactions, such as difficulty breathing, swelling of the face or throat, or rash
• Severe diarrhea, which may be accompanied by abdominal pain or fever
• Seizures or changes in mental status

If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Meroev-TZ may interact with other medications, including:

• Probenecid: This medication may increase the levels of Meropenem in the blood, potentially leading to an increased risk of side effects.
• Valproic acid: Concurrent use of Valproic acid and Meropenem may reduce the levels of Valproic acid in the blood, potentially affecting its effectiveness.

Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, vitamins, and herbal supplements, to avoid any potential interactions.

Precautions

Before using Meroev-TZ, discuss your medical history and any underlying conditions with your healthcare provider. Inform them if you have a history of allergies, kidney problems, or seizures.

Meroev-TZ should be used with caution in patients with a known hypersensitivity to any carbapenem antibiotics or beta-lactamase inhibitors.

Note that Meroev-TZ may decrease the effectiveness of certain types of birth control. Additional contraceptive measures should be used while taking this medication.

Storage

Meroev-TZ should be stored at room temperature, away from direct light and moisture. It should be kept out of the reach of children.

Patient Tips

• Follow the instructions provided by your healthcare provider regarding the dosage and duration of treatment.
• complete the full course of treatment, even if symptoms improve.
• If you miss a dose, contact your healthcare provider for further instructions.
• Report any persistent or worsening side effects to your healthcare provider.
• Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
• Store the medication properly at room temperature, away from light and moisture.
• Do not share this medication with others, as it is prescribed specifically for your condition.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Meronem IV 1g Powder for solution for injection or infusion (Health Professionals SmPC) Available at:
• Meropenem (Drugs.com) [Accessed 22 Jun. 2024] (online) Available at:
• meropenem vial (RX) [Accessed 29 Jun. 2024] (online) Available at:
• Meropenem and Vaborbactam Injection (MedlinePlus) [Accessed 23 Jun. 2024] (online) Available at:
• Pascale R, Giannella M, Bartoletti M, Viale P, Pea F. Use of meropenem in treating carbapenem-resistant Enterobacteriaceae infections. Expert Rev Anti Infect Ther. 2019 Oct;17(10):819-827. doi: 10.1080/14787210.2019.1673731. Epub 2019 Oct 8. [Accessed 0 Jun. 2024] Available at: