Metaglez Forte Tablet

Introduction

Metaglez Forte is a medication that combines two active ingredients, Glipizide and Metformin. Glipizide belongs to a class of drugs called sulfonylureas, while Metformin is classified as a biguanide. This combination medication is commonly prescribed to help manage blood sugar levels in patients with type 2 diabetes.

Uses

Metaglez Forte is primarily used to control blood sugar levels in individuals with type 2 diabetes. It helps lower blood glucose by increasing the release of insulin from the pancreas and improving the body’s response to insulin. By managing blood sugar levels, Metaglez Forte can help prevent complications associated with diabetes, such as kidney damage, nerve problems, and vision loss.

Dosage and Administration

The dosage of Metaglez Forte may vary depending on individual patient factors and the specific instructions provided by the healthcare professional. Follow the prescribed dosage and administration instructions carefully. Typically, the medication is taken orally with meals to reduce the risk of stomach upset.

Mechanism of Action

Glipizide, one of the active ingredients in Metaglez Forte, works by stimulating the beta cells in the pancreas to release more insulin. This helps decrease blood sugar levels by increasing the amount of insulin available to help glucose enter the cells.

Metformin, the other active ingredient, works by reducing the amount of glucose produced by the liver and improving the body’s sensitivity to insulin. It also helps lower blood sugar levels by increasing the uptake and utilization of glucose by the muscles.

Together, Glipizide and Metformin work synergistically to provide better blood sugar control in patients with type 2 diabetes.

Side Effects

Common side effects may include gastrointestinal symptoms such as nausea, diarrhea, and stomach upset. These side effects are generally mild and may resolve on their own as the body adjusts to the medication.

In some cases, serious side effects may occur. These may include signs of low blood sugar (hypoglycemia) such as dizziness, confusion, sweating, and rapid heartbeat. Promptly inform your healthcare provider if you experience any of these symptoms.

Drug Interactions

Metaglez Forte may interact with certain medications, including other diabetes medications, certain antibiotics, and certain heart medications. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions.

Some drug interactions may increase the risk of low blood sugar (hypoglycemia) or affect the effectiveness of Metaglez Forte. Your healthcare provider can provide guidance on any necessary adjustments to your medication regimen to minimize the risk of interactions.

Precautions

Before starting Metaglez Forte, inform your healthcare provider about any medical conditions you have, especially liver or kidney problems. This medication may not be suitable for individuals with certain medical conditions or allergies.

Metaglez Forte should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Discuss the risks and benefits of this medication with your healthcare provider before starting treatment.

Storage

Metaglez Forte should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of the reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

Here are a few tips to help you get the most out of your Metaglez Forte medication:

• Follow your healthcare provider’s instructions regarding dosage and administration.
• Take the medication with meals to reduce the risk of stomach upset.
• Keep track of your blood sugar levels regularly and report any significant changes to your healthcare provider.
• Be aware of the signs and symptoms of low blood sugar (hypoglycemia) and know how to respond if they occur.
• Inform your healthcare provider about all the medications, including over-the-counter drugs and herbal supplements, that you are taking to avoid potential drug interactions.
• Attend regular check-ups with your healthcare provider to monitor your diabetes management and make any necessary adjustments to your treatment plan.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Metformin: a medicine to treat type 2 diabetes (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
• Competact 15 mg/850 mg film-coated tablets (Health Professionals SmPC) Available at:
• Glipizide (Drugs.com) [Accessed 16 Jun. 2024] (online) Available at:
• glipizide (glucotrol) (RX) [Accessed 9 Jun. 2024] (online) Available at:
• Glipizide (MedlinePlus) [Accessed 3 Jun. 2024] (online) Available at:
• Foster RH, Plosker GL. Glipizide. A review of the pharmacoeconomic implications of the extended-release formulation in type 2 diabetes mellitus. Pharmacoeconomics. 2000 Sep;18(3):289-306. doi: 10.2165/00019053-200018030-00008. [Accessed 9 Jun. 2024] Available at: