Migject Plus 40mg/10mg Injection

Introduction

Migject Plus is a prescription medication that combines two active ingredients: Propranolol and Flunarizine. Propranolol is a beta-blocker that helps to reduce heart rate and blood pressure, while Flunarizine is a calcium channel blocker that helps to prevent migraine attacks. This combination medication is primarily used to manage migraines and certain cardiovascular conditions.

Uses

Migject Plus is prescribed for the following conditions:

• Migraines: It can help prevent migraine attacks and reduce their frequency and severity.
• Cardiovascular conditions: It may be used to manage certain heart conditions, such as angina (chest pain) and hypertension (high blood pressure).

Dosage and Administration

Migject Plus should be administered by a healthcare professional. The dosage and administration instructions may vary depending on the individual’s condition and response to treatment. Follow the instructions provided by your healthcare provider.

Mechanism of Action

Propranolol, one of the active ingredients in Migject Plus, works by blocking the action of certain chemicals in the body that can increase heart rate and blood pressure. This helps to reduce the workload on the heart and relax the blood vessels, resulting in a decrease in blood pressure. Flunarizine, the other active ingredient, works by blocking calcium channels in the blood vessels and reducing the amount of calcium that enters the cells. This helps to prevent the constriction of blood vessels, which can contribute to migraines.

Side Effects

Migject Plus may cause side effects in some individuals. Common side effects may include:

• Fatigue
• Dizziness
• Nausea
• Constipation
• Dry mouth

Serious side effects are rare but may include:

• Slow heart rate
• Low blood pressure
• Changes in mood or mental health
• Shortness of breath
• Swelling of the ankles or feet

If you experience any severe or persistent side effects, seek medical attention immediately.

Drug Interactions

Migject Plus may interact with other medications and substances. Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some common drug interactions with Migject Plus include:

• Other beta-blockers
• Calcium channel blockers
• Antidepressants
• Antiarrhythmic drugs

These are not the only possible drug interactions. Your healthcare provider can provide you with a comprehensive list of potential interactions and advise you accordingly.

Precautions

Before using Migject Plus, consider certain precautions:

• Contraindications: This medication should not be used in individuals with a known allergy to Propranolol, Flunarizine, or any other ingredients in the injection.
• Medical conditions: Inform your healthcare provider if you have a history of certain medical conditions, such as asthma, heart failure, or liver disease. They will determine if Migject Plus is suitable for you.
• Pregnancy and breastfeeding: Discuss the risks and benefits of using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
• Interactions with other medications: As mentioned earlier, this medication may interact with other medications. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

Storage

Migject Plus should be stored according to the instructions provided on the packaging. In general, it should be stored at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Follow the instructions provided by your healthcare provider regarding the use of Migject Plus.
• Keep track of any side effects you experience and inform your healthcare provider.
• If you miss a dose, contact your healthcare provider for further guidance.
• Do not stop using this medication abruptly without consulting your healthcare provider.
• If you have any concerns or questions about Migject Plus, don’t hesitate to reach out to your healthcare provider for clarification.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Propranolol: medicine for heart problems, anxiety and migraine (NHS UK) [Accessed 3 Jun. 2024] (online) Available at:
• Bedranol 160mg SR Capsules (Health Professionals SmPC) Available at:
• Flunarizine (International database) (Drugs.com) [Accessed 24 Jun. 2024] (online) Available at:
• propranolol (RX) [Accessed 5 Jun. 2024] (online) Available at:
• LactMed: Drugs and Lactation Database (National Library of Medicine) [Accessed 1 Jun. 2024] (online) Available at:
• Deligianni CI, Sacco S, Ekizoglu E, Uluduz D, Gil-Gouveia R, MaassenVanDenBrink A, Ornello R, Sanchez-Del-Rio M, Reuter U, Versijpt J, de Vries T, Hussain M, Zeraatkar D, Lampl C. European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 2: flunarizine. J Headache Pain. 2023 Sep 19;24(1):128. doi: 10.1186/s10194-023-01657-3. [Accessed 0 Jun. 2024] Available at: