Migron 5mg/10mg Tablet

Introduction

Migron is a prescription medication that combines two active ingredients: Flunarizine and Domperidone. Flunarizine is a calcium channel blocker that is used to prevent migraine headaches, while Domperidone is a medication that helps to relieve nausea and vomiting. This combination medication is commonly prescribed to provide relief for individuals suffering from migraines accompanied by nausea or vomiting.

Uses

Migron is primarily prescribed for the following conditions:

• Migraine headaches with associated nausea or vomiting

This medication is specifically designed to provide relief for individuals experiencing migraines accompanied by symptoms of nausea or vomiting. It helps to reduce the frequency and severity of migraine attacks and alleviate associated discomfort.

Dosage and Administration

The recommended dosage of Migron may vary depending on individual factors such as age, medical condition, and response to treatment. Follow the instructions provided by your healthcare professional or the information on the medication label.

Typically, the initial recommended dose for adults is one tablet per day, taken orally with or without food. However, consult with your healthcare professional to determine the appropriate dosage for your specific situation.

Mechanism of Action

Migron contains two active ingredients: Flunarizine and Domperidone. Flunarizine works by blocking calcium channels in the brain, which helps to reduce the hyperexcitability of nerve cells and prevent the onset of migraines. Domperidone acts as a dopamine antagonist and helps to relieve nausea and vomiting by blocking dopamine receptors in the brain and digestive system.

By combining these two medications, Migron provides a dual mechanism of action to effectively manage migraines and associated symptoms.

Side Effects

Common side effects may include drowsiness, dizziness, dry mouth, and constipation. These side effects are usually mild and subside as your body adjusts to the medication. However, if they persist or become bothersome, consult your healthcare professional.

In rare cases, Migron may cause serious side effects such as movement disorders, abnormal heart rhythm, or signs of an allergic reaction (e.g., rash, itching, swelling). If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications may interact with Migron and potentially increase the risk of side effects or affect its effectiveness.

Common drug interactions include:

• Other medications that prolong the QT interval (e.g., certain antibiotics, antipsychotics, antifungal medications)
• Medications that increase the concentration of domperidone in the blood (e.g., certain antifungal medications, antidepressants, antiviral medications)

To ensure your safety and the effectiveness of Migron. Disclose all relevant information about your current medications to your healthcare professional.

Precautions

Before starting Migron. Discuss your medical history and any existing conditions with your healthcare professional. Certain precautions need to be considered, including:

• Contraindications: Migron should not be used in individuals with a known hypersensitivity to flunarizine, domperidone, or any of the other ingredients in the medication. It is also contraindicated in individuals with a history of movement disorders, Parkinson’s disease, or heart rhythm abnormalities.
• Interactions with other medications: Migron may interact with other medications, as mentioned earlier. Inform your healthcare professional about all the medications you are currently taking to avoid potential interactions.
• Pregnancy and breastfeeding: Migron should be used with caution during pregnancy and breastfeeding. Discuss the potential risks and benefits with your healthcare professional before taking this medication if you are pregnant or breastfeeding.

Storage

Migron should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use Migron after the expiration date printed on the packaging. If you have any unused or expired medication, please consult your pharmacist for proper disposal.

Patient Tips

• Take Migron as prescribed by your healthcare professional. Do not exceed the recommended dosage.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Avoid consuming alcohol while taking Migron, as it may increase the risk of side effects such as drowsiness and dizziness.
• If you experience any unusual or persistent side effects, contact your healthcare professional for further guidance.
• Follow a healthy lifestyle, including regular exercise, a balanced diet, and adequate sleep, to help manage migraines and improve overall well-being.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Domperidone: anti-sickness medicine for nausea and vomiting (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
• Domperidone 10 mg film-coated tablets (Health Professionals SmPC) Available at:
• Domperidone (Drugs.com) [Accessed 4 Jun. 2024] (online) Available at:
• Definitions of Digestive Terms (International Foundation for Gastrointestinal Disorders) [Accessed 3 Jun. 2024] (online) Available at:
• Puoti MG, Assa A, Benninga M, Broekaert IJ, Carpi FJM, Deganello Saccomani M, Dolinsek J, Homan M, Mas E, Miele E, Tzivinikos C, Thomson M, Borrelli O. Drugs in Focus: Domperidone. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):e13-e22. doi: 10.1097/MPG.0000000000003822. Epub 2023 May 9. [Accessed 7 Jun. 2024] Available at: