Nelova 150mg Capsule

Introduction

Nelova is a prescription medication that contains the active ingredient Nilotinib. It is available under the brand name Nelova. This medication is primarily used in the treatment of a specific type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).

Uses

Nelova is prescribed to treat adults with Ph+ CML who have not responded to other medications or have developed resistance to them. It is specifically used in the chronic phase of the disease.

Dosage and Administration

The dosage of Nelova is individualized based on various factors such as the patient’s overall health, response to treatment, and other medications they may be taking. Follow the instructions provided by your healthcare professional.

The usual recommended starting dose of Nelova is 300 mg taken orally twice daily, approximately 12 hours apart. The capsules should be swallowed whole with a glass of water, and it is recommended to take them with food to minimize stomach upset.

Mechanism of Action

Nelova belongs to a class of medications known as tyrosine kinase inhibitors. It works by blocking the activity of a specific protein called BCR-ABL tyrosine kinase, which is responsible for the abnormal growth and division of cancer cells in Ph+ CML. By inhibiting this protein, Nelova helps to slow down the progression of the disease.

Side Effects

Common side effects that may occur include nausea, vomiting, diarrhea, fatigue, headache, muscle and joint pain, rash, and fluid retention. These side effects are generally manageable and tend to improve with time.

However, there are also more serious side effects that can occur. These may include low blood cell counts, liver problems, heart problems, pancreatitis, and bleeding. Seek immediate medical attention if you experience any severe or persistent side effects.

Drug Interactions

Nelova may interact with other medications, including over-the-counter drugs, herbal supplements, and certain foods. Inform your healthcare professional about all the medications and supplements you are taking to avoid potential interactions. Common drug interactions with Nelova include medications that affect liver enzymes, certain antibiotics, antifungal medications, and certain antidepressants.

Precautions

Before starting Nelova, discuss your medical history and any allergies with your healthcare professional. This medication may not be suitable for everyone, and there are certain precautions to consider.

Nelova should not be used by individuals with a known hypersensitivity to Nilotinib or any of its components. Inform your healthcare professional if you have liver problems, heart problems, or a history of pancreatitis.

Additionally, Nelova may interact with other medications, including certain heart medications, antacids, and grapefruit juice. Follow your healthcare professional’s advice regarding any necessary precautions or adjustments to your treatment plan.

Storage

Patient Tips

• Take Nelova exactly as prescribed by your healthcare professional.
• Swallow the capsules whole with a glass of water, and take them with food to minimize stomach upset.
• If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to make up for a missed one.
• attend all scheduled appointments with your healthcare professional for monitoring and dose adjustments if necessary.
• Inform your healthcare professional about any new or worsening symptoms you experience while taking Nelova.
• Store the medication in a safe place, away from children and pets, and check the expiration date before use.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Mastocytosis – Treatment (NHS UK) [Accessed 1 Jun. 2024] (online) Available at:
• Tasigna 150mg Hard Capsules (Health Professionals SmPC) Available at:
• Nilotinib (Drugs.com) [Accessed 19 Jun. 2024] (online) Available at:
• nilotinib capsule (RX) [Accessed 29 Jun. 2024] (online) Available at:
• Nilotinib (MedlinePlus) [Accessed 8 Jun. 2024] (online) Available at:
• Kantarjian HM, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Boquimpani C, Pasquini R, Clark RE, Dubruille V, Flinn IW, Kyrcz-Krzemien S, Medras E, Zanichelli M, Bendit I, Cacciatore S, Titorenko K, Aimone P, Saglio G, Hochhaus A. Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis. Leukemia. 2021 Feb;35(2):440-453. doi: 10.1038/s41375-020-01111-2. Epub 2021 Jan 7. [Accessed 16 Jun. 2024] Available at: