Not-Now Tablet Combipack

Introduction

Not-Now Combipack is a prescription medication that contains two active ingredients: Mifepristone and Misoprostol. It is commonly used in the field of reproductive health.

Uses

Not-Now Combipack is primarily prescribed for two main purposes:

• Medical Abortion: It is used to terminate an early pregnancy up to 70 days from the start of the last menstrual period. Mifepristone works by blocking the hormone progesterone, which is necessary for maintaining a pregnancy. Misoprostol helps to expel the pregnancy tissue from the uterus.
• Cervical Ripening and Induction of Labor: In some cases, Not-Now Combipack may be used to prepare the cervix for labor induction or to induce labor in certain situations.

Dosage and Administration

The dosage and administration of Not-Now Combipack should be determined by a healthcare professional and should be based on individual circumstances. Follow the specific instructions provided by your healthcare provider.

For medical abortion, the usual recommended dosage is 1 tablet of Mifepristone (200 mg) followed by 4 tablets of Misoprostol (each tablet containing 200 mcg). The Misoprostol tablets are usually taken 24 to 48 hours after taking Mifepristone.

For cervical ripening and induction of labor, the dosage and administration may vary based on the specific situation and the healthcare provider’s instructions.

Mechanism of Action

Mifepristone, the active ingredient in Not-Now Combipack, works by blocking the action of progesterone, a hormone necessary for maintaining a pregnancy. This leads to changes in the uterus, including softening and opening of the cervix, and detachment of the pregnancy tissue from the uterine wall.

Misoprostol, another active ingredient in Not-Now Combipack, causes contractions of the uterus, helping to expel the pregnancy tissue.

Side Effects

Common side effects may include nausea, vomiting, abdominal pain, diarrhea, and headache. These side effects are usually temporary and may subside on their own.

However, some side effects may be serious and require immediate medical attention. These may include severe abdominal pain, heavy or prolonged vaginal bleeding, fever, chills, or signs of infection.

If you experience any of these serious side effects or have concerns about any side effects, contact your healthcare provider immediately.

Drug Interactions

Not-Now Combipack may interact with certain medications, including but not limited to:

• Anticoagulants: Not-Now Combipack may enhance the effects of anticoagulant medications, increasing the risk of bleeding.
• Corticosteroids: There may be an increased risk of adrenal insufficiency when Not-Now Combipack is used with corticosteroids.
• Certain anticonvulsant medications: Not-Now Combipack may reduce the effectiveness of some anticonvulsant medications.

Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, to avoid potential drug interactions.

Precautions

Before taking Not-Now Combipack, consider the following precautions:

• Allergies: If you have known allergies to Mifepristone, Misoprostol, or any other medications, inform your healthcare provider.
• Ectopic Pregnancy: Not-Now Combipack should not be used if you have an ectopic pregnancy (a pregnancy outside the uterus).
• Blood Clotting Disorders: Inform your healthcare provider if you have a history of blood clotting disorders, as Not-Now Combipack may increase the risk of blood clots.
• Medical Conditions: Inform your healthcare provider about any medical conditions you have, including liver or kidney problems, asthma, or any other chronic conditions.
• Interactions with Other Medications and Substances: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products. Also, inform them about any substances you use, such as tobacco, alcohol, or recreational drugs.

Storage

Not-Now Combipack should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it out of the reach of children and pets. Follow any specific storage instructions provided by your healthcare provider or pharmacist.

Patient Tips

Here are some additional tips for patients using Not-Now Combipack:

• Take the medication as prescribed by your healthcare provider and follow the recommended dosage instructions.
• If you experience any unusual or severe side effects, contact your healthcare provider immediately.
• attend follow-up appointments with your healthcare provider to ensure the treatment is successful and to address any concerns or questions you may have.
• If you have any doubts or questions about the medication, do not hesitate to consult your healthcare provider or pharmacist for clarification.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Medabon – Combipack of Mifepristone 200 mg tablet and Misoprostol 4 x 0.2 mg vaginal tablets (Health Professionals SmPC) Available at:
• Mifepristone (Drugs.com) [Accessed 4 Jun. 2024] (online) Available at:
• mifepristone 200 mg tablet abortifacients (RX) [Accessed 18 Jun. 2024] (online) Available at:
• Mifepristone (Mifeprex) [Accessed 14 Jun. 2024] (online) Available at:
• Cameron S, Reynolds-Wright J. Mifepristone at home. BMJ. 2022 Mar 29;376:o819. doi: 10.1136/bmj.o819. [Accessed 25 Jun. 2024] Available at: