Notipra Suspension

Introduction

Notipra is a prescription medication containing two active ingredients: Ofloxacin and Tinidazole. It is commonly used to treat a variety of bacterial and protozoal infections. Notipra is available under this brand name and may also be sold under other brand names.

Uses

Notipra is prescribed for the treatment of various infections caused by susceptible bacteria and protozoa. It is commonly used to treat:

• Urinary tract infections: Notipra can help eliminate the bacteria that cause urinary tract infections, such as cystitis and urethritis.
• Gastrointestinal infections: This medication can be used to treat infections of the digestive tract, including diarrhea caused by certain bacteria and protozoa.
• Sexually transmitted infections: Notipra may be prescribed to treat certain sexually transmitted infections, such as bacterial vaginosis and trichomoniasis.

Dosage and Administration

follow the instructions provided by your healthcare professional when taking Notipra. The dosage and duration of treatment will depend on the specific infection being treated, as well as your overall health and medical history.

Generally, the recommended dosage for adults is 10 ml (containing 200 mg Ofloxacin and 600 mg Tinidazole), taken orally, twice daily. The suspension should be shaken well before use, and it is typically taken with food to help minimize stomach upset.

Complete the full course of treatment, even if you start feeling better before the medication is finished. If you have any questions about the dosage or administration, consult your healthcare provider.

Mechanism of Action

Notipra contains two active ingredients, Ofloxacin and Tinidazole, which work together to combat bacterial and protozoal infections.

• Ofloxacin: This medication belongs to a class of antibiotics called fluoroquinolones. It works by inhibiting the activity of certain enzymes in bacteria, preventing them from growing and multiplying.
• Tinidazole: Tinidazole is an antiprotozoal medication that works by interfering with the DNA synthesis of the microorganisms, leading to their destruction.

By targeting both bacteria and protozoa, Notipra effectively fights against a wide range of infections.

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Stomach pain
• Headache
• Dizziness

If any of these side effects persist or worsen. Inform your healthcare provider.

In rare cases, Notipra may cause more serious side effects, such as:

• Allergic reactions: This may include rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Central nervous system effects: Some individuals may experience confusion, hallucinations, or seizures. If you experience any of these symptoms, contact your healthcare provider immediately.

Drug Interactions

Notipra may interact with certain medications, potentially altering their effectiveness or increasing the risk of side effects. Inform your healthcare provider of all the medications you are currently taking, including prescription, over-the-counter, and herbal products.

Some common drug interactions with Notipra may include:

• Warfarin: This medication used to prevent blood clots may have an increased risk of bleeding when taken in combination with Notipra. Close monitoring of blood clotting parameters may be necessary.
• Antacids: Taking antacids containing aluminum, calcium, or magnesium may reduce the absorption of Notipra. It is recommended to take Notipra at least 2 hours before or 2 hours after taking antacids.
• Other medications: Notipra may interact with other medications that affect the liver enzymes responsible for metabolizing drugs. This can alter the blood levels of both Notipra and the interacting medication, potentially leading to increased or decreased effects.

Consult your healthcare provider or pharmacist for a comprehensive list of potential drug interactions.

Precautions

Before taking Notipra, inform your healthcare provider if you have any known allergies to Ofloxacin, Tinidazole, or any other medications. Additionally, inform your healthcare provider about any other medical conditions you may have, especially:

• Liver disease
• Kidney disease
• Central nervous system disorders

Certain precautions should be taken when using Notipra, including:

• Contraindications: Notipra should not be used in individuals with a known allergy to Ofloxacin, Tinidazole, or any other ingredients in the medication. It is also contraindicated in pregnant women, breastfeeding women, and children under the age of 18.
• Alcohol: It is recommended to avoid alcohol while taking Notipra, as it may increase the risk of certain side effects such as dizziness and nausea.

Always follow your healthcare provider’s instructions and guidelines when using Notipra.

Storage

Notipra should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use Notipra after the expiration date printed on the packaging.

Patient Tips

When taking Notipra, consider the following tips to ensure safe and effective use:

• Take the medication with food to help minimize stomach upset.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not share your medication with others, even if they have similar symptoms.
• If you experience any unusual or persistent side effects, contact your healthcare provider.
• Follow your healthcare provider’s instructions regarding the duration of treatment and any additional precautions or lifestyle modifications.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• EXOCIN® 3 mg/ml Eye Drops, Solution. (Health Professionals SmPC) Available at:
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• ofloxacin (RX) [Accessed 17 Jun. 2024] (online) Available at:
• Ofloxacin (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Hsiao SH, Chang CM, Tsao CJ, Lee YY, Hsu MY, Wu TJ. Acute rhabdomyolysis associated with ofloxacin/levofloxacin therapy. Ann Pharmacother. 2005 Jan;39(1):146-9. doi: 10.1345/aph.1E285. Epub 2004 Nov 23. [Accessed 13 Jun. 2024] Available at: