Olabuzz 150 Tablet

Introduction

Olabuzz is a prescription medication that contains Olaparib as its active ingredient. It is available in tablet form and is used for the treatment of certain types of cancer.

Uses

Olabuzz is prescribed for the treatment of advanced ovarian, fallopian tube, or primary peritoneal cancer in adults who have undergone previous chemotherapy. It is also indicated for the maintenance treatment of adult patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer.

Dosage and Administration

The recommended dosage of Olabuzz is 300 mg taken orally twice daily. It should be taken with or without food. The tablets should be swallowed whole and should not be crushed, chewed, or broken.

Mechanism of Action

Olaparib, the active ingredient in Olabuzz, is a poly (ADP-ribose) polymerase (PARP) inhibitor. It works by blocking the activity of PARP enzymes, which are involved in repairing damaged DNA in cells. By inhibiting PARP, Olaparib helps prevent cancer cells from repairing their DNA, leading to their death.

Side Effects

Common side effects of Olabuzz may include nausea, fatigue, vomiting, diarrhea, loss of appetite, and headache. These side effects are usually mild to moderate and may resolve on their own. However, if any of these side effects persist or worsen, consult your healthcare provider.

Serious side effects of Olabuzz may include lung problems, such as pneumonitis or interstitial lung disease, and bone marrow suppression, which can lead to low blood cell counts. These side effects are rare but can be severe. If you experience symptoms such as persistent cough, shortness of breath, fever, or unusual bleeding or bruising, seek immediate medical attention.

Drug Interactions

Olabuzz may interact with certain medications, including strong CYP3A inhibitors and inducers. Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential drug interactions.

Precautions

Before starting treatment with Olabuzz, inform your healthcare provider about any medical conditions you have, especially if you have a history of lung problems, bone marrow problems, or allergies to medications.

Olabuzz should not be used during pregnancy, as it may cause harm to the unborn baby. Use effective contraception during treatment and for a certain period after discontinuation of the medication.

Storage

Patient Tips

• Take Olabuzz exactly as prescribed by your healthcare provider.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Inform your healthcare provider about any new or worsening symptoms you experience during treatment.
• Follow all safety precautions and instructions provided by your healthcare provider while taking Olabuzz.
• Do not stop taking the medication without consulting your healthcare provider.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Lynparza 100mg Film-Coated Tablets (Health Professionals SmPC) Available at:
• Olaparib (Drugs.com) [Accessed 7 Jun. 2024] (online) Available at:
• olaparib 150 mg tablet (RX) [Accessed 14 Jun. 2024] (online) Available at:
• Olaparib (MedlinePlus) [Accessed 28 Jun. 2024] (online) Available at:
• Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P. Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. N Engl J Med. 2017 Aug 10;377(6):523-533. doi: 10.1056/NEJMoa1706450. Epub 2017 Jun 4. [Accessed 25 Jun. 2024] Available at: