Palbace 125mg Tablet

Introduction

Palbace is a prescription medication that contains the active ingredient Palbociclib. It is available under the brand name Palbace. This medication is primarily used in the treatment of certain types of breast cancer.

Uses

Palbace is prescribed to treat hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in postmenopausal women. It is used in combination with other medications, such as an aromatase inhibitor, for this purpose.

Dosage and Administration

The recommended dosage of Palbace is 125 mg taken orally once daily for 21 consecutive days followed by a break of 7 days. This 28-day cycle is repeated as long as the medication continues to be effective and well-tolerated.

The tablets should be swallowed whole with a glass of water, and they can be taken with or without food. Follow the specific dosage instructions provided by your healthcare provider.

Mechanism of Action

Palbociclib, the active ingredient in Palbace, is a targeted therapy that works by inhibiting certain proteins called cyclin-dependent kinases (CDK) 4 and 6. These proteins play a role in regulating cell division and growth. By blocking CDK4 and CDK6, Palbociclib helps to slow down the growth of cancer cells in hormone receptor-positive breast cancer.

Side Effects

Common side effects that may occur include:

• Fatigue or tiredness
• Nausea
• Diarrhea
• Hair loss
• Infections, such as urinary tract infections
• Decreased appetite
• Headache

Serious side effects are rare but can occur. If you experience any of the following, contact your healthcare provider immediately:

• Severe allergic reactions, such as difficulty breathing or swelling of the face, lips, tongue, or throat
• Severe or persistent diarrhea
• Signs of liver problems, such as yellowing of the skin or eyes, dark urine, or abdominal pain
• Signs of lung problems, such as difficulty breathing or coughing
• Signs of infection, such as fever or chills

report any side effects to your healthcare provider, as they can provide guidance and support.

Drug Interactions

Palbace may interact with other medications. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Palbace.

Some common and serious drug interactions may occur with Palbace. These can include interactions with medications that affect liver enzymes, such as certain antifungal medications, antibiotics, and certain antidepressants. Your healthcare provider will review your medication list and determine the appropriate course of action to manage any potential interactions.

Precautions

Before using Palbace, discuss your medical history and any current medications or supplements with your healthcare provider. Certain conditions, such as liver problems or a history of heart disease, may affect the use of this medication.

Palbace is not recommended for use during pregnancy or while breastfeeding. Use effective contraception during treatment with this medication, as it may cause harm to an unborn baby.

Avoid grapefruit or grapefruit juice while taking Palbace, as it may increase the levels of the medication in your blood and potentially lead to increased side effects.

Storage

Palbace should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Palbace exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your doctor.
• attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your treatment.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Store the medication in its original packaging to protect it from light and moisture.
• If you have any questions or concerns regarding your treatment with Palbace, do not hesitate to reach out to your healthcare provider for guidance and support.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• IBRANCE 100 mg film-coated tablets (Health Professionals SmPC) Available at:
• Palbociclib (Drugs.com) [Accessed 10 Jun. 2024] (online) Available at:
• palbociclib capsule (RX) [Accessed 2 Jun. 2024] (online) Available at:
• Palbociclib (MedlinePlus) [Accessed 9 Jun. 2024] (online) Available at:
• Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ. Palbociclib and Letrozole in Advanced Breast Cancer. N Engl J Med. 2016 Nov 17;375(20):1925-1936. doi: 10.1056/NEJMoa1607303. [Accessed 6 Jun. 2024] Available at: