Pigolyn 0.2% Cream

Introduction

Pigolyn is a prescription medication that contains the active ingredient Trioxasalen. Trioxasalen is a photosensitizing agent that helps to treat certain skin conditions when used in combination with ultraviolet (UV) light therapy. It is available under the brand name Pigolyn.

Uses

Pigolyn is primarily used to treat a skin condition called vitiligo. Vitiligo is a long-term skin disorder characterized by the loss of skin color in patches. This cream, when used in conjunction with controlled exposure to UVA or UVB light, helps to repigment the affected areas of the skin. Note that Pigolyn should only be used under the guidance and supervision of a healthcare professional.

Dosage and Administration

The dosage and administration of Pigolyn will be determined by your healthcare provider based on your specific condition and needs. Follow their instructions carefully. Typically, the cream is applied thinly to the affected areas of the skin and then exposed to UVA or UVB light. The duration and frequency of treatment sessions will depend on various factors, including the severity of your condition. It is important not to exceed the recommended dosage or duration of treatment without consulting your healthcare provider.

Mechanism of Action

Pigolyn contains Trioxasalen, which is a photosensitizing agent. When applied to the skin and exposed to UVA or UVB light, Trioxasalen interacts with the light to form compounds that help to stimulate the production of melanin in the skin. Melanin is the pigment responsible for giving color to the skin, hair, and eyes. By increasing the production of melanin, Pigolyn helps to repigment the areas affected by vitiligo.

Side Effects

Common side effects may include redness, itching, or a burning sensation at the application site. These side effects are usually mild and temporary. However, if you experience any severe or persistent side effects, such as blistering, swelling, or severe skin irritation, seek medical attention immediately.

Drug Interactions

Pigolyn may interact with certain medications. Inform your healthcare provider about all the medications you are currently taking, including prescription and over-the-counter medications, as well as any herbal supplements. Some medications, such as certain antibiotics or antidepressants, may increase your sensitivity to light, which can affect the effectiveness and safety of Pigolyn. Your healthcare provider will be able to advise you on any potential drug interactions.

Precautions

Before using Pigolyn, inform your healthcare provider about any known allergies or sensitivities to medications. Additionally, discuss any medical conditions you have, especially if you have a history of skin cancer, liver disease, or any other skin disorders. This medication should not be used during pregnancy or while breastfeeding without the guidance of a healthcare professional. Avoid excessive sun exposure or tanning beds while using Pigolyn, as it can increase your sensitivity to light.

Storage

Patient Tips

• Follow the instructions provided by your healthcare provider regarding the application of Pigolyn and the exposure to UVA or UVB light.
• Avoid applying the cream to areas of the skin that are not affected by vitiligo.
• Protect your skin from excessive sun exposure by using sunscreen and wearing protective clothing.
• If you experience any unusual or severe side effects, contact your healthcare provider immediately.
• Attend all follow-up appointments with your healthcare provider to monitor your progress and adjust the treatment if necessary.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Hadjipavlou-Litina D, E Bariamis S, Militsopoulou M, Athanassopoulos CM, Papaioannou D. Trioxsalen derivatives with lipoxygenase inhibitory activity. J Enzyme Inhib Med Chem. 2009 Dec;24(6):1351-6. doi: 10.3109/14756360902932776. [Accessed 3 Jun. 2024] Available at:
• Sánchez Ruderisch H, Schwarz C, Shang J, Tebbe B. Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes. Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):335-41. doi: 10.1159/000064538. [Accessed 2 Jun. 2024] Available at:
• Hannuksela-Svahn A, Sigurgeirsson B, Pukkala E, Lindelöf B, Berne B, Hannuksela M, Poikolainen K, Karvonen J. Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. Br J Dermatol. 1999 Sep;141(3):497-501. doi: 10.1046/j.1365-2133.1999.03044.x. [Accessed 11 Jun. 2024] Available at:
• Skogh M. Trioxsalen vs methoxsalen in the treatment of psoriasis. Arch Dermatol. 1978 Sep;114(9):1399. [Accessed 11 Jun. 2024] Available at: