Pivikto 200mg Tablet

Introduction

Pivikto is a prescription medication that contains the active ingredient Alpelisib. It is available under the brand name Pivikto. This medication is primarily used for the treatment of advanced breast cancer that is hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-), and has a mutation in the PIK3CA gene.

Uses

Pivikto is prescribed for the treatment of advanced breast cancer in postmenopausal women and men. It is specifically indicated for individuals with HR+/HER2- breast cancer that has spread to other parts of the body and carries a PIK3CA mutation.

Dosage and Administration

The dosage of Pivikto may vary depending on individual factors such as the patient’s overall health, the severity of the condition, and other medications being taken. Follow the instructions provided by your healthcare provider. Typically, the recommended dose is 300 milligrams (equivalent to two 150-milligram tablets) taken orally once daily with food. The tablets should be swallowed whole and not crushed, chewed, or divided.

Mechanism of Action

Alpelisib, the active ingredient in Pivikto, belongs to a class of medications known as PI3K inhibitors. It works by blocking the activity of a protein called PI3K, which plays a crucial role in the growth and survival of cancer cells. By inhibiting PI3K, Pivikto helps to slow down the progression of advanced breast cancer with a PIK3CA mutation.

Side Effects

Common side effects that have been reported include:

• Diarrhea
• Nausea
• Vomiting
• Fatigue
• Rash
• Decreased appetite

note that not all individuals will experience these side effects, and their severity may vary. If any of these side effects persist or worsen, it is recommended to consult your healthcare provider for further guidance.

In rare cases, Pivikto may cause more serious side effects. These can include:

• Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
• Severe diarrhea or dehydration
• Severe skin reactions (e.g., blistering, peeling, or sores on the skin)
• Liver problems (e.g., yellowing of the skin or eyes, dark urine, abdominal pain)

If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications may interact with Pivikto and potentially increase the risk of side effects or affect its effectiveness. Some common and serious drug interactions include:

• Strong CYP3A4 inhibitors: Medications that inhibit CYP3A4 enzyme activity can increase the concentration of Alpelisib in the blood, potentially leading to increased side effects. Discuss all medications you are taking with your healthcare provider to ensure there are no contraindications.

Precautions

Before starting treatment with Pivikto, inform your healthcare provider about any existing medical conditions or allergies you may have. Additionally, inform them about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Here are some important precautions to consider:

• Contraindications: Pivikto is contraindicated in individuals who are allergic to Alpelisib or any other ingredients in the formulation. It is also not recommended for use during pregnancy or breastfeeding.
• Liver problems: Pivikto may cause liver problems. Regular liver function tests may be recommended by your healthcare provider to monitor your liver health during treatment.
• Other medications: Pivikto may interact with other medications, including over-the-counter drugs and herbal supplements. Discuss all medications you are taking with your healthcare provider to ensure there are no contraindications or potential drug interactions.

Storage

Pivikto should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of the reach of children and pets. Do not use Pivikto beyond the expiration date printed on the packaging.

Patient Tips

• Follow your healthcare provider’s instructions: take Pivikto exactly as prescribed. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• Take with food: Pivikto should be taken with food to help improve absorption and reduce the risk of stomach upset.
• Stay hydrated: drink plenty of fluids to stay hydrated while taking Pivikto, especially if you experience diarrhea or vomiting.
• Report any side effects: If you experience any side effects or have concerns about the medication, discuss them with your healthcare provider. They can provide guidance and support to ensure your safety and well-being.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Piqray 150 mg film-coated tablets (Health Professionals SmPC) Available at:
• Alpelisib (Drugs.com) [Accessed 18 Jun. 2024] (online) Available at:
• alpelisib 200 mg/day (200 mg x 1) tablet (RX) [Accessed 25 Jun. 2024] (online) Available at:
• Alpelisib (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• André F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS, Iwata H, Conte P, Mayer IA, Kaufman B, Yamashita T, Lu YS, Inoue K, Takahashi M, Pápai Z, Longin AS, Mills D, Wilke C, Hirawat S, Juric D; SOLAR-1 Study Group. Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer. N Engl J Med. 2019 May 16;380(20):1929-1940. doi: 10.1056/NEJMoa1813904. [Accessed 6 Jun. 2024] Available at: