Planep Tablet

Introduction

Planep is a prescription medication that contains the active ingredient Eplerenone. It is available under the brand name Planep. This medication is primarily used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in patients with heart failure.

Uses

Planep is prescribed to manage hypertension, a condition characterized by high blood pressure. It is also used in patients with congestive heart failure to reduce the risk of cardiovascular events such as heart attack and stroke. This medication helps to control blood pressure and improve heart function, thereby reducing the strain on the heart.

Dosage and Administration

The recommended dosage of Planep may vary depending on individual factors such as the severity of the condition being treated and the patient’s response to the medication. Follow the instructions provided by your healthcare provider. Generally, the starting dose for hypertension is 50 mg once daily, which may be adjusted as necessary. For heart failure, the initial dose is usually 25 mg once daily, increasing to 50 mg once daily after 4 weeks if tolerated.

Planep should be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless directed by your healthcare provider.

Mechanism of Action

Eplerenone, the active ingredient in Planep, belongs to a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a hormone that regulates salt and water balance in the body. By inhibiting aldosterone, Planep helps to reduce sodium and water retention, leading to a decrease in blood pressure and improved heart function.

Side Effects

Common side effects may include dizziness, headache, fatigue, and diarrhea. These side effects are usually mild and temporary. However, if they persist or worsen, consult your healthcare provider.

Serious side effects may include hyperkalemia (high levels of potassium in the blood), allergic reactions, and liver problems. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or yellowing of the skin or eyes.

Drug Interactions

Planep may interact with other medications, including certain diuretics, potassium supplements, and medications that increase potassium levels. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements. They can help determine if any potential interactions may occur and adjust your treatment plan accordingly.

Precautions

Before taking Planep, inform your healthcare provider about any allergies you may have, especially to eplerenone or similar medications. Additionally, discuss your medical history, including any kidney or liver problems, electrolyte imbalances, or heart rhythm disorders.

Planep should not be used in patients with severe kidney problems, high blood potassium levels, or who are taking certain medications that may interact with eplerenone. Follow your healthcare provider’s instructions and avoid any contraindications.

Storage

Planep should be stored at room temperature, away from moisture and heat. Keep the medication out of the reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Planep exactly as prescribed by your healthcare provider. Do not change the dose or stop taking the medication without consulting them.
• It may take some time for Planep to show its full effect. Be patient and continue taking the medication as directed.
• Do not consume excessive amounts of potassium-rich foods or potassium supplements while taking Planep, unless specifically instructed by your healthcare provider.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• If you have any concerns or questions about Planep, speak with your healthcare provider or pharmacist. They are best equipped to provide you with personalized advice and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Eplerenone: a medicine to treat heart failure (NHS UK) [Accessed 28 Jun. 2024] (online) Available at:
• Eplerenone 25 mg film-coated tablets (Health Professionals SmPC) Available at:
• Eplerenone (Drugs.com) [Accessed 18 Jun. 2024] (online) Available at:
• eplerenone (inspra) (RX) [Accessed 6 Jun. 2024] (online) Available at:
• Eplerenone (MedlinePlus) [Accessed 27 Jun. 2024] (online) Available at:
• Provenzano M, Puchades MJ, Garofalo C, Jongs N, D’Marco L, Andreucci M, De Nicola L, Gorriz JL, Heerspink HJL; ROTATE-3 study group; ROTATE-3 study group members. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial. J Am Soc Nephrol. 2022 Aug;33(8):1569-1580. doi: 10.1681/ASN.2022020207. Epub 2022 Apr 19. [Accessed 7 Jun. 2024] Available at: