Pre Aldonil 150mg/150mg Tablet

Introduction

Pre Aldonil is a prescription medication that combines two active ingredients: Epalrestat and Pregabalin. Epalrestat is an aldose reductase inhibitor, while Pregabalin is an anticonvulsant and analgesic. This medication is primarily used for the treatment of diabetic neuropathy, a condition that affects the nerves and is commonly seen in individuals with diabetes.

Uses

Pre Aldonil is prescribed to patients with diabetic neuropathy, a complication of diabetes that can cause symptoms such as pain, numbness, and tingling in the hands and feet. By combining Epalrestat and Pregabalin, this medication helps manage the neuropathic pain associated with diabetic neuropathy, improving the overall quality of life for individuals with this condition.

Dosage and Administration

follow your healthcare provider’s instructions when taking Pre Aldonil. The dosage and administration may vary depending on your specific condition and medical history. Generally, the recommended dose is one tablet taken orally, usually once or twice daily. It is advisable to take this medication with food to improve absorption and reduce the risk of stomach upset.

Mechanism of Action

Pre Aldonil works through its two active ingredients, Epalrestat and Pregabalin, to provide therapeutic effects. Epalrestat works by inhibiting the enzyme aldose reductase, which plays a role in the development of diabetic neuropathy. By inhibiting this enzyme, Epalrestat helps reduce the accumulation of harmful sorbitol in the nerves, thereby preventing nerve damage and alleviating symptoms.

Pregabalin, on the other hand, works by binding to certain calcium channels in the central nervous system. By doing so, it helps regulate the release of neurotransmitters involved in pain signaling, thereby reducing the intensity of neuropathic pain experienced by individuals with diabetic neuropathy.

Side Effects

Common side effects may include dizziness, drowsiness, headache, blurred vision, and dry mouth. These side effects are generally mild and transient.

However, be aware of serious side effects that may occur. If you experience any of the following symptoms, you should seek immediate medical attention: severe allergic reactions, difficulty breathing, swelling of the face, lips, tongue, or throat, suicidal thoughts, or changes in mood or behavior.

Drug Interactions

Pre Aldonil may interact with certain medications or substances, potentially affecting their efficacy or increasing the risk of side effects. Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking before starting Pre Aldonil. Some common drug interactions may include interactions with opioids, sedatives, and other medications that cause central nervous system depression.

Precautions

Before taking Pre Aldonil, discuss any existing medical conditions or allergies with your healthcare provider. This medication may not be suitable for individuals with a history of kidney problems, liver problems, or certain mental health disorders. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of this medication during pregnancy and lactation has not been established.

Additionally, Pre Aldonil may interact with other medications, including over-the-counter drugs and herbal supplements. Avoid or use caution when taking certain medications in combination with Pre Aldonil. Your healthcare provider can provide specific guidance based on your individual situation.

Storage

Pre Aldonil should be stored at room temperature, away from moisture and heat. Keep this medication out of reach of children and pets. Do not use Pre Aldonil if the packaging is damaged or if the tablets are past their expiration date. Proper storage helps maintain the effectiveness and safety of the medication.

Patient Tips

Here are a few tips to help you make the most of your treatment with Pre Aldonil:

• Follow your healthcare provider’s instructions regarding the dosage and administration of Pre Aldonil.
• Take the medication with food to improve absorption and reduce the risk of stomach upset.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Do not stop taking Pre Aldonil without consulting your healthcare provider, as abrupt discontinuation may result in withdrawal symptoms.
• If you have any concerns or questions about your treatment, do not hesitate to reach out to your healthcare provider for clarification.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Pregabalin: medicine to treat epilepsy and anxiety (NHS UK) [Accessed 18 Jun. 2024] (online) Available at:
• Alzain 100 mg Capsules, Hard (Health Professionals SmPC) Available at:
• Pregabalin (Drugs.com) [Accessed 8 Jun. 2024] (online) Available at:
• pregabalin (lyrica) (RX) [Accessed 18 Jun. 2024] (online) Available at:
• Pregabalin (MedlinePlus) [Accessed 18 Jun. 2024] (online) Available at:
• Steele JW, Faulds D, Goa KL. Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus. Drugs Aging. 1993 Nov-Dec;3(6):532-55. doi: 10.2165/00002512-199303060-00007. [Accessed 2 Jun. 2024] Available at: