Regonat Tablet

Introduction

Regonat is a prescription medication that contains the active ingredient Regorafenib. It is available under the brand name Regonat. This medication is primarily used in the treatment of certain types of cancer.

Uses

Regonat is prescribed for the treatment of metastatic colorectal cancer (CRC) that has progressed even after receiving other cancer treatments. It may also be used to treat advanced gastrointestinal stromal tumors (GIST) that cannot be surgically removed or have spread to other parts of the body.

Dosage and Administration

The dosage of Regonat is individualized based on various factors such as body weight, overall health, and response to treatment. Follow the specific instructions provided by your healthcare professional. Regonat is taken orally with a full glass of water, usually once daily, either with or without food. Swallow the tablet whole; do not crush, chew, or break it.

Mechanism of Action

Regorafenib, the active ingredient in Regonat, belongs to a class of medications called multikinase inhibitors. It works by inhibiting the activity of certain proteins that are involved in the growth and spread of cancer cells. By blocking these proteins, Regorafenib helps to slow down or stop the growth of cancer cells.

Side Effects

Regonat may cause side effects in some patients. Common side effects may include fatigue, loss of appetite, nausea, diarrhea, high blood pressure, and hand-foot skin reaction (redness, swelling, or pain on the palms of the hands or soles of the feet). Report any unusual or severe side effects to your healthcare professional.

Serious side effects may occur, although they are less common. These can include severe bleeding, liver problems, heart problems, and gastrointestinal perforation (a hole or tear in the stomach or intestines). If you experience any signs of a serious side effect, such as severe bleeding, chest pain, difficulty breathing, or severe abdominal pain, seek immediate medical attention.

Drug Interactions

Regonat may interact with other medications, including over-the-counter drugs, herbal supplements, and vitamins. Inform your healthcare professional about all the medications you are currently taking to avoid potential drug interactions. Some medications that may interact with Regonat include certain anticoagulants, antifungal medications, and certain antibiotics. Your healthcare professional will closely monitor your medication regimen to minimize the risk of drug interactions.

Precautions

Before starting Regonat, discuss your medical history and any existing conditions with your healthcare professional. Inform them if you have a history of bleeding problems, liver disease, heart problems, or any other significant medical conditions. Regonat should not be used during pregnancy or breastfeeding, as it may harm the unborn baby or pass into breast milk.

Regonat may interact with certain medications, including other cancer treatments, blood thinners, and medications that affect liver function. Inform your healthcare professional about all the medications and supplements you are taking to avoid potential interactions.

Storage

Regonat should be stored at room temperature, away from moisture and heat. Keep it in its original packaging and out of the reach of children. Do not use Regonat if it has expired or if the packaging is damaged.

Patient Tips

• Take Regonat exactly as prescribed by your healthcare professional. Do not change the dosage or stop taking the medication without consulting them first.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Regular check-ups and laboratory tests may be required to monitor your response to Regonat and detect any potential side effects.
• maintain a healthy lifestyle while taking Regonat. Eat a balanced diet, exercise regularly, and follow any additional recommendations provided by your healthcare professional.
• If you have any questions or concerns about Regonat or your treatment, do not hesitate to reach out to your healthcare professional for clarification. They are there to support you throughout your treatment journey.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Regorafenib (Drugs.com) [Accessed 30 Jun. 2024] (online) Available at:
• regorafenib tablet (RX) [Accessed 25 Jun. 2024] (online) Available at:
• Regorafenib (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D; CORRECT Study Group. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013 Jan 26;381(9863):303-12. doi: 10.1016/S0140-6736(12)61900-X. Epub 2012 Nov 22. [Accessed 29 Jun. 2024] Available at: