Rytstat 25mg Tablet

Introduction

Rytstat is a prescription medication that contains the active ingredient Desidustat. It is available in tablet form and is primarily used for the treatment of certain types of anemia in patients with chronic kidney disease.

Uses

Rytstat is prescribed to treat anemia associated with chronic kidney disease. It helps to increase the production of red blood cells in the body, which can improve symptoms such as fatigue, weakness, and shortness of breath.

Dosage and Administration

The dosage of Rytstat may vary depending on the individual patient and their specific condition. Follow the instructions provided by your healthcare professional. Typically, the recommended starting dose is one tablet taken orally once a day. Your healthcare professional may adjust the dosage based on your response to the medication. Take the tablet at the same time each day to maintain consistent levels of the medication in your body.

Mechanism of Action

Desidustat, the active ingredient in Rytstat, works by inhibiting the enzyme responsible for the breakdown of hypoxia-inducible factor (HIF). This leads to an increase in the production of erythropoietin, a hormone that stimulates the production of red blood cells. By increasing the production of red blood cells, Rytstat helps to alleviate anemia in patients with chronic kidney disease.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, headache, and dizziness. If any of these side effects persist or worsen, consult your healthcare professional.

In some cases, Rytstat may cause more serious side effects. These can include allergic reactions, chest pain, difficulty breathing, swelling of the face, lips, tongue, or throat, and severe skin reactions. If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Rytstat may interact with certain medications, which can affect how the medication works or increase the risk of side effects. Inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal products. Common drug interactions may occur with medications that affect the liver or kidney function, such as certain antibiotics, antifungal medications, and antiviral medications. Discuss potential drug interactions with your healthcare professional to ensure the safe and effective use of Rytstat.

Precautions

Before starting treatment with Rytstat, inform your healthcare professional about any existing medical conditions, allergies, or medications you are taking. This includes any history of liver or kidney disease, heart problems, or bleeding disorders.

Rytstat is not recommended for use in pregnant or breastfeeding women, as its safety in these populations has not been established. Discuss the potential risks and benefits with your healthcare professional before using this medication.

Storage

Rytstat should be stored at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of reach of children. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Rytstat exactly as prescribed by your healthcare professional. Do not take more or less than the recommended dose.
• attend regular follow-up appointments with your healthcare professional to monitor your response to the medication and adjust the dosage if necessary.
• If you miss a dose of Rytstat, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not stop taking Rytstat without first consulting your healthcare professional, as this may affect the effectiveness of the medication.
• If you have any questions or concerns about Rytstat, do not hesitate to contact your healthcare professional for further guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Dhillon S. Desidustat: First Approval. Drugs. 2022 Jul;82(11):1207-1212. doi: 10.1007/s40265-022-01744-w. [Accessed 13 Jun. 2024] Available at:
• Parmar DV, Kansagra KA, Patel JC, Joshi SN, Sharma NS, Shelat AD, Patel NB, Nakrani VB, Shaikh FA, Patel HV; on behalf of the ZYAN1 Trial Investigators. Outcomes of Desidustat Treatment in People with Anemia and Chronic Kidney Disease: A Phase 2 Study. Am J Nephrol. 2019;49(6):470-478. doi: 10.1159/000500232. Epub 2019 May 21. [Accessed 28 Jun. 2024] Available at:
• Patel VJ, Joharapurkar A, Kshirsagar SG, Patel MS, Savsani HH, Dodiya HS, Rakhasiya MH, Kajavadara C, Valani D, Jain MR. HIF-PHD inhibitor desidustat ameliorates iron deficiency anemia. Toxicol Appl Pharmacol. 2024 Feb;483:116832. doi: 10.1016/j.taap.2024.116832. Epub 2024 Jan 22. [Accessed 26 Jun. 2024] Available at:
• Agrawal D, Varade D, Shah H, Nazar A, Krishnan J, Shukla V, Ramakrishna C, Bandara Galahitiyawa MC, Mavani SB, Rajanna S, Jikki P, De Silva S, Ruhela V, Koradia P, Kansagra K, Kanani P, Sharma N, Zala K, Parmar D; Study Investigator Group. Desidustat in Anemia due to Non-Dialysis-Dependent Chronic Kidney Disease: A Phase 3 Study (DREAM-ND). Am J Nephrol. 2022;53(5):352-360. doi: 10.1159/000523961. Epub 2022 Apr 22. [Accessed 14 Jun. 2024] Available at: