Selepeg 200 Tablet

Introduction

Selepeg is a prescription medication that contains the active ingredient Selexipag.

Uses

Selepeg is primarily prescribed to treat pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries that carry blood from the heart to the lungs. This medication helps to improve exercise capacity and delay the progression of PAH.

Dosage and Administration

The dosage of Selepeg may vary depending on the individual’s specific condition, response to treatment, and other factors. Follow the instructions provided by your healthcare professional or as indicated on the prescription label.

Generally, Selepeg is taken orally with or without food. It is usually taken twice daily, approximately 12 hours apart. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless instructed to do so by your doctor.

Mechanism of Action

Selexipag, the active ingredient in Selepeg, belongs to a class of medications known as prostacyclin receptor agonists. It works by activating certain receptors in the blood vessels of the lungs, leading to the relaxation and widening of these vessels. This helps to reduce the high blood pressure in the pulmonary arteries and improve blood flow, ultimately easing the symptoms of PAH.

Side Effects

Selepeg may cause side effects in some individuals. Common side effects may include headache, diarrhea, nausea, vomiting, joint pain, muscle pain, and flushing. These side effects are usually mild and may improve as your body adjusts to the medication. However, if they persist or worsen, inform your doctor.

Serious side effects are rare but can occur. Contact your healthcare professional immediately if you experience symptoms such as severe chest pain, shortness of breath, fainting, swelling of the legs or ankles, or signs of liver problems (e.g., yellowing of the skin or eyes, dark urine, persistent nausea or vomiting).

Drug Interactions

inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with Selepeg and potentially increase the risk of side effects or affect its effectiveness.

Common drug interactions may include strong inhibitors or inducers of the enzyme CYP2C8, such as fluconazole, rifampin, and carbamazepine. These medications may alter the metabolism of Selexipag in the body, leading to potential drug interactions. Consult your doctor or pharmacist to ensure the safe use of Selepeg.

Precautions

Before starting treatment with Selepeg, inform your healthcare professional about any existing medical conditions, allergies, or medications you are taking. This medication may not be suitable for individuals with certain medical conditions or those who are allergic to its components.

Selepeg should be used with caution in patients with liver or kidney problems, as well as in pregnant or breastfeeding women. Discuss the potential risks and benefits of using this medication in these situations with your doctor.

Storage

Patient Tips

• Take Selepeg as prescribed by your healthcare professional. Do not change the dosage or stop taking the medication without consulting your doctor.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• attend regular follow-up appointments with your doctor to monitor your progress and any potential side effects.
• Avoid drinking grapefruit juice while taking Selepeg, as it may increase the level of the medication in your blood and potentially increase the risk of side effects.
• If you experience any new or concerning symptoms while taking Selepeg, contact your healthcare professional for further guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Uptravi 1,400 microgram Film-coated Tablets (Great Britain) (Health Professionals SmPC) Available at:
• Selexipag oral/injection (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• selexipag 1,800 mcg intravenous solution (RX) [Accessed 8 Jun. 2024] (online) Available at:
• Selexipag Injection (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2015 Dec 24;373(26):2522-33. doi: 10.1056/NEJMoa1503184. [Accessed 6 Jun. 2024] Available at: