Introduction
Sitahenz PM is a prescription medication that contains three active ingredients: Metformin, Pioglitazone, and Sitagliptin. It is commonly used to manage blood sugar levels in patients with type 2 diabetes. Sitahenz PM helps to improve insulin sensitivity, reduce glucose production in the liver, and increase glucose utilization in the body.
Uses
Sitahenz PM is primarily prescribed for the treatment of type 2 diabetes mellitus. It is used to lower blood sugar levels in patients who are unable to control their diabetes through diet and exercise alone. This medication is typically used in combination with a healthy diet and regular exercise to help manage blood sugar levels effectively.
Dosage and Administration
The recommended dosage of Sitahenz PM may vary depending on individual factors such as age, medical history, and response to treatment. Follow the instructions provided by your healthcare provider. Generally, the initial dose for adults is one tablet taken orally once daily with a meal. Your healthcare provider may adjust the dose as needed to achieve optimal blood sugar control.
Mechanism of Action
Sitahenz PM works through multiple mechanisms to improve blood sugar control. Metformin helps to reduce glucose production in the liver and enhances insulin sensitivity in peripheral tissues. Pioglitazone improves insulin sensitivity in the body’s cells and reduces insulin resistance. Sitagliptin increases the levels of incretin hormones, which stimulate insulin release and inhibit the release of glucagon, leading to lowered blood sugar levels.
Side Effects
Common side effects may include nausea, diarrhea, abdominal discomfort, and headache. These side effects are usually mild and temporary. However, if they persist or worsen. Consult your healthcare provider. Serious side effects such as lactic acidosis (rare but potentially life-threatening) and heart failure (especially in patients with a history of heart problems) may occur. Seek immediate medical attention if you experience symptoms such as severe weakness, difficulty breathing, swelling, or rapid weight gain.
Drug Interactions
Sitahenz PM may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some common drug interactions include:
- Insulin or other oral antidiabetic medications: Sitahenz PM may enhance the blood sugar-lowering effects of these medications, increasing the risk of hypoglycemia.
- Certain heart medications (e.g., Nifedipine, Gemfibrozil): These medications may increase the concentration of Pioglitazone in the body, leading to an increased risk of side effects.
- Medications that affect kidney function (e.g., Cimetidine): These medications may affect the elimination of Metformin from the body, leading to increased levels and a higher risk of side effects.
This is not an exhaustive list of drug interactions. Consult your healthcare provider or pharmacist for a complete list of potential interactions.
Precautions
Before starting treatment with Sitahenz PM, inform your healthcare provider about any existing medical conditions, including kidney problems, liver disease, heart disease, or a history of heart failure. This medication may not be suitable for everyone, and your healthcare provider will evaluate the benefits and risks before prescribing it. Sitahenz PM should be used with caution in patients with a history of pancreatitis or bladder cancer.
Storage
Sitahenz PM should be stored at room temperature, away from direct light and moisture. Keep the medication out of reach of children and pets. Do not use Sitahenz PM if the packaging is damaged or if the tablets have expired. Proper storage helps maintain the effectiveness and safety of the medication.
Patient Tips
- Take Sitahenz PM exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or change the dosing schedule without consulting your healthcare provider.
- monitor your blood sugar levels regularly and report any significant changes to your healthcare provider.
- Maintain a healthy diet and engage in regular exercise to support the effectiveness of Sitahenz PM.
- If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- Do not stop taking Sitahenz PM without consulting your healthcare provider, as this may lead to uncontrolled blood sugar levels.
- If you experience any unusual or persistent side effects, contact your healthcare provider promptly.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Metformin: a medicine to treat type 2 diabetes (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
- Competact 15 mg/850 mg film-coated tablets (Health Professionals SmPC) Available at:
- Metformin (Drugs.com) [Accessed 6 Jun. 2024] (online) Available at:
- metformin (RX) [Accessed 21 Jun. 2024] (online) Available at:
- Metformin (MedlinePlus) [Accessed 2 Jun. 2024] (online) Available at:
- LaMoia TE, Shulman GI. Cellular and Molecular Mechanisms of Metformin Action. Endocr Rev. 2021 Jan 28;42(1):77-96. doi: 10.1210/endrev/bnaa023. [Accessed 21 Jun. 2024] Available at:
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